Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Haybaeck, J; Roessner, A.
[Malignant round cell tumors : The Ewing sarcoma and beyond].
Pathologe. 2020; 41(2):116-122
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Haybäck Johannes

Dimensions Citations:

Plum Analytics:
Ewing sarcomas are highly malignant tumors that are mainly found in children and adolescents. In addition to early clinical diagnosis, correct histopathological and molecular genetic classification is the most important step. Although EWSR1-FLI1 fusion is by far the most common detectable change, there are also other representatives of the Ewing sarcoma family that cannot be distinguished histopathologically and immunohistochemically from classical Ewing sarcomas and that have different molecular genetic profiles. Although a precise molecular genetic differentiation of the various representatives of small round blue cell tumors does not yet lead to any change in the standard chemotherapy and surgical treatment applied, it does allow an estimation of the prognosis and will probably contribute in the future to an even more individualized treatment of Ewing sarcomas within the framework of personalized medicine.

Find related publications in this database (Keywords)
Ewing sarcoma
Atypical variants
Molecular genetics
New therapy approaches
Fusion oncoprotein
© Med Uni Graz Impressum