Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Wilkinson, C; Bhatty, A; Batra, G; Aktaa, S; Smith, AB; Dwight, J; Ruciński, M; Chappell, S; Alfredsson, J; Erlinge, D; Ferreira, J; Guðmundsdóttir, IJ; Hrafnkelsdóttir, ÞJ; Ingimarsdóttir, IJ; Irs, A; Jánosi, A; Járai, Z; Oliveira-Santos, M; Popescu, BA; Vasko, P; Vinereanu, D; Yap, J; Bugiardini, R; Cenko, E; Nadarajah, R; Sydes, MR; James, S; Maggioni, AP; Wallentin, L; Casadei, B; Gale, CP, , Global, Cardiovascular, Outcomes, Consortium, and, in, collaboration, with, ACNAP, ACVC, EACVI, EAPC, EAPCI, EHRA, ESC, Committee, for, Young, CV, Professionals, ESC, Registry, Committee, HFA, ESC, Patient, Forum, and, these, Working, Groups:, aorta, and, peripheral, vascular, diseases, atherosclerosis, and, vascular, biology, cardiac, cellular, electrophysiology, cardiovascular, pharmacotherapy, cardiovascular, regenerative, and, restorative, medicine, cardiovascular, surgery, cellular, biology, of, the, heart, e-cardiology, myocardial, function, pulmonary, circulation, and, right, ventricular, function, and, thrombosis .
Definitions of clinical study outcome measures for cardiovascular diseases: the European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart).
Eur Heart J. 2025; 46(2):190-214 Doi: 10.1093/eurheartj/ehae724 [OPEN ACCESS]
PubMed PUBMED Central FullText FullText_MUG

 

Autor*innen der Med Uni Graz:
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
BACKGROUND AND AIMS: Standardized definitions for outcome measures in randomized clinical trials and observational studies are essential for robust and valid evaluation of medical products, interventions, care, and outcomes. The European Unified Registries for Heart Care Evaluation and Randomised Trials (EuroHeart) project of the European Society of Cardiology aimed to create international data standards for cardiovascular clinical study outcome measures. METHODS: The EuroHeart methods for data standard development were used. From a Global Cardiovascular Outcomes Consortium of 82 experts, five Working Groups were formed to identify and define key outcome measures for: cardiovascular disease (generic outcomes), acute coronary syndrome and percutaneous coronary intervention (ACS/PCI), atrial fibrillation (AF), heart failure (HF) and transcatheter aortic valve implantation (TAVI). A systematic review of the literature informed a modified Delphi method to reach consensus on a final set of variables. For each variable, the Working Group provided a definition and categorized the variable as mandatory (Level 1) or optional (Level 2) based on its clinical importance and feasibility. RESULTS: Across the five domains, 24 Level 1 (generic: 5, ACS/PCI: 8, AF: 2; HF: 5, TAVI: 4) and 48 Level 2 (generic: 18, ACS-PCI: 7, AF: 6, HF: 2, TAVI: 15) outcome measures were defined. CONCLUSIONS: Internationally derived and endorsed definitions for outcome measures for a range of common cardiovascular diseases and interventions are presented. These may be used for data alignment to enable high-quality observational and randomized clinical research, audit, and quality improvement for patient benefit.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Randomized Controlled Trials as Topic - administration & dosage
Registries - administration & dosage
Cardiovascular Diseases - therapy
Europe - administration & dosage
Outcome Assessment, Health Care - administration & dosage
Transcatheter Aortic Valve Replacement - administration & dosage
Heart Failure - therapy
Acute Coronary Syndrome - therapy
Percutaneous Coronary Intervention - administration & dosage
Delphi Technique - administration & dosage

© Med Uni Graz • Impressum