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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mizuno, S; Gras, L; Baaij, LGA; Koster, L; D'Souza, A; Hari, PN; Estrada-Merly, N; Saber, W; Cowan, AJ; Iida, M; Okamoto, S; Takamatsu, H; Kawamura, K; Kodera, Y; Hamad, N; Ko, BS; Liam, C; Ho, KW; Goh, AS; Keat, TS; Elhaddad, AM; Bazarbachi, A; Chaudhry, BQUN; Alfar, R; Bekadja, MA; Benakli, M; Ortiz, CAF; Riva, E; Verburgh, E; Galeano, S; Bass, F; Mian, H; McCurdy, A; Wang, FR; Neumann, D; Koh, MBC; Snowden, JA; Schönland, S; McLornan, DP; Hayden, PJ; Balari, AMS; Greinix, HT; Aljurf, M; Atsuta, Y; Rondelli, D; Niederwieser, DW; Garderet, L.
The impact of age on survival and excess mortality after autologous hematopoietic cell transplantation in newly diagnosed multiple myeloma patients.
Haematologica. 2025;
Doi: 10.3324/haematol.2025.288041
PubMed
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- Autor*innen der Med Uni Graz:
- Greinix Hildegard
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- Abstract:
- Despite the availability of novel agents, autologous hematopoietic cell transplantation (auto-HCT) remains the standard of care in newly diagnosed multiple myeloma (MM) patients. The impact of age on overall survival (OS), progression-free survival (PFS), relapse incidence, non-relapse mortality (NRM), and excess mortality (taking account of general population mortality) was investigated using information on 61,797 MM patients transplanted between 2013 and 2017. The median age at auto-HCT was 60.8 (range: 18.1-83.2) years of whom 2.0% were 18-39 years, 68.9% 40-64 years, 21.8% 65-69 years, 6.5% 70-74 years, and 0.8% ≥75 years of age, respectively. The corresponding OS probabilities at three years were 85.9%, 82.8%, 81.1%, 78.4%, and 74.8%, respectively (p<0.001). Excess mortality cumulative incidences were 13.1%, 15.0%, 14.6%, 15.0%, and 14.1% at three years, respectively (p=0.67). In multivariable analyses, older age was a significant risk factor for OS, PFS, and NRM but not for excess mortality or relapse risk. Our results indicate that advanced age alone should not preclude the use of auto-HCT in patients with MM.