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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Shahbazi, Khamas, S; Brinkman, P; Neerincx, AH; Vijverberg, SJH; Hashimoto, S; Blankestijn, JM; Duitman, JW; Dekker, T; Smids, BS; Terheggen-Lagro, SWJ; Lutter, R; Metwally, NKA; Sondaal, F; Haarman, EG; Sterk, PJ; Adcock, IM; Auffray, C; Bang, C; Bansal, AT; Buntrock-Döpke, H; Bønnelykke, K; Bush, A; Chawes, BL; Chung, KF; Corcuera-Elosegui, P; Dahlén, SE; Djukanovic, R; Fleming, LJ; Fowler, SJ; Franke, A; Frey, U; Gorenjak, M; Brandstetter, S; Harner, S; Hedlin, G; Kabesch, M; Zounemat-Kermani, N; Kheirolldein, P; Kiefer, A; Konradsen, JR; Kraneveld, AD; López-Fernández, L; Murray, CS; Nordlund, B; Pino-Yanes, M; Potočnik, U; Roberts, G; Stokholm, J; Sørensen, SJ; Sardón-Prado, O; Shaw, DE; Singer, F; Sousa, AR; Thorsen, J; Toncheva, AA; Vissing, NH; Wolff, C; Abdel-Aziz, MI; Maitland-van, der, Zee, AH, , SysPharmPediA, and, U‐BIOPRED, Consortia.
Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History.
Allergy. 2025; Doi: 10.1111/all.70004
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Autor*innen der Med Uni Graz:
Singer Florian
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Abstract:
BACKGROUND: Early identification of children at risk of asthma attacks is important for optimizing treatment strategies. We aimed to integrate salivary microbiome and serum inflammatory mediator profiles with asthma attacks history to develop a comprehensive predictive model for future attacks. METHODS: This study contained a discovery (SysPharmPediA) and a replication phase (U-BIOPRED). School-aged children with asthma were classified into at risk and no-risk groups, based on the presence or absence of one or more severe attacks during one-year follow-up. Prediction models were developed using random forest on the training set (70%) with data on past asthma attacks, microbiome composition, serum inflammatory mediator levels, and their combinations and then tested on the rest of the population (30%). Outcomes were replicated in a subset of children with severe asthma from U-BIOPRED. RESULTS: Complete data were available for 154 children (SysPharmPediA = 121, U-BIOPRED = 33). In discovery, the model based on past attacks resulted in an area under the receiving characteristic curve (AUROCC) ~ 0.7. Models including six salivary bacteria or six inflammatory mediators achieved similar results. The combined model incorporating seven features, past asthma attacks, Capnocytophaga, Corynebacterium, and Cardiobacterium, TIMP-4, VEGF, and MIP-3β achieved the highest accuracy with AUROCC ~0.87. The combined model in the U-BIOPRED limited to available inflammatory mediators (VEGF), and incorporating past asthma attacks, Capnocytophaga, Corynebacterium, and Cardiobacterium, resulted in an AUROCC of 0.84. CONCLUSION: Serum inflammatory mediators and salivary microbiome complement asthma attacks history for predicting future attacks. These results highlight the imperative for continued investigation into oral microbiota and its interaction with the immune system.

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