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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Reininger, R; Varga, EM; Zach, M; Balic, N; Lindemeier, AD; Swoboda, I; Grönlund, H; van Hage, M; Rumpold, H; Valenta, R; Spitzauer, S.
Detection of an allergen in dog dander that cross-reacts with the major cat allergen, Fel d 1.
Clin Exp Allergy. 2007; 37(1): 116-124. Doi: 10.1111/j.1365-2222.2006.02611.x
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Co-Autor*innen der Med Uni Graz
Varga Eva-Maria
Zach Maximilian

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BACKGROUND: A considerable proportion of animal-allergic patients are sensitized to both cat and dog allergens but knowledge about cross-reactive allergens in cat and dog dander is limited. OBJECTIVE: To investigate whether dog dander contains an allergen that cross-reacts with the major cat allergen, Fel d 1. METHODS: Recombinant Fel d 1 with the same immunological properties as natural Fel d 1 was used for quantitative (CAP) IgE competition experiments performed with sera obtained from cat-allergic patients (n=36). A Fel d 1 cross-reactive dog allergen was characterized by one- and two-dimensional immunoblotting using rFel d 1 for IgE inhibition experiments and with monospecific, polyclonal rabbit anti-recombinant Fel d 1 antibodies. RESULTS: In 25% of Fel d 1-reactive cat-allergic patients, more than 50% inhibition of IgE reactivity to dog allergens was achieved with recombinant Fel d 1. An Fel d 1 cross-reactive 20 kDa allergen with a pI of approximately 3.4 was detected in dander extracts of several different dog breeds. CONCLUSION: This is the first report demonstrating the presence of an Fel d 1-like allergen in dog dander extracts, which may be responsible for double positivity to cat and dog in serology. However, the clinical relevance of this cross-sensitization needs to be confirmed. These results are important for the diagnostic and therapeutic use of dog dander allergen extracts.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Allergens - immunology
Animals - immunology
Cats - immunology
Child - immunology
Child, Preschool - immunology
Cross Reactions - immunology
Dogs - immunology
Dust - immunology
Electrophoresis, Gel, Two-Dimensional - immunology
Environmental Pollution - immunology
Female - immunology
Glycoproteins - immunology
Humans - immunology
Hypersensitivity - immunology
Immune Sera - immunology
Immunoblotting - immunology
Immunoglobulin E - blood
Male - blood
Rabbits - blood
Recombinant Proteins - immunology
Serum Albumin - immunology
Skin Tests - immunology

Find related publications in this database (Keywords)
cat allergy
dog allergy
Fel d 1
major cat allergen
recombinant allergen
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