Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Berger, M; Pirpamer, L; Hofer, E; Ropele, S; Duering, M; Gesierich, B; Pasternak, O; Enzinger, C; Schmidt, R; Koini, M.
Free water diffusion MRI and executive function with a speed component in healthy aging.
Neuroimage. 2022; 257:119303
Doi: 10.1016/j.neuroimage.2022.119303
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- Führende Autor*innen der Med Uni Graz
- Berger Martin
- Schmidt Reinhold
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Hofer Edith
- Koini Marisa
- Pirpamer Lukas
- Ropele Stefan
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- Abstract:
- Extracellular free water (FW) increases are suggested to better provide pathophysiological information in brain aging than conventional biomarkers such as fractional anisotropy. The aim of the present study was to determine the relationship between conventional biomarkers, FW in white matter hyperintensities (WMH), FW in normal appearing white matter (NAWM) and in white matter tracts and executive functions (EF) with a speed component in elderly persons. We examined 226 healthy elderly participants (median age 69.83 years, IQR: 56.99-74.42) who underwent brain MRI and neuropsychological examination. FW in WMH and in NAWM as well as FW corrected diffusion metrics and measures derived from conventional MRI (white matter hyperintensities, brain volume, lacunes) were used in partial correlation (adjusted for age) to assess their correlation with EF with a speed component. Random forest analysis was used to assess the relative importance of these variables as determinants. Lastly, linear regression analyses of FW in white matter tracts corrected for risk factors of cognitive and white matter deterioration, were used to examine the role of specific tracts on EF with a speed component, which were then ranked with random forest regression. Partial correlation analyses revealed that almost all imaging metrics showed a significant association with EF with a speed component (r = -0.213 - 0.266). Random forest regression highlighted FW in WMH and in NAWM as most important among all diffusion and structural MRI metrics. The fornix (R2=0.421, p = 0.018) and the corpus callosum (genu (R2 = 0.418, p = 0.021), prefrontal (R2 = 0.416, p = 0.026), premotor (R2 = 0.418, p = 0.021)) were associated with EF with a speed component in tract based regression analyses and had highest variables importance. In a normal aging population FW in WMH and NAWM is more closely related to EF with a speed component than standard DTI and brain structural measures. Higher amounts of FW in the fornix and the frontal part of the corpus callosum leads to deteriorating EF with a speed component.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Biomarkers - administration & dosage
- Diffusion Magnetic Resonance Imaging - administration & dosage
- Diffusion Tensor Imaging - methods
- Executive Function - physiology
- Healthy Aging - administration & dosage
- Humans - administration & dosage
- Leukoaraiosis - administration & dosage
- Water - administration & dosage
- White Matter - diagnostic imaging
- Find related publications in this database (Keywords)
- Free water diffusion
- Cognitive speed
- Corpus callosum
- Fornix
- Executive functions
- Aging