Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
COVIDSurg Collaborative;GlobalSurg Collaborative.
SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Anaesthesia. 2022; 77(1): 28-39.
Doi: 10.1111/anae.15563
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- Study Group Mitglieder der Med Uni Graz:
- Andrianakis Alexandros
- Belarmino Armin
- Brinskelle Petra
- Castellani Christoph
- Cohnert Tina Ulrike
- Fediuk Melanie
- Fink Andrea
- Holzmeister Clemens
- Kahn Judith
- Leithner Andreas
- Lindenmann Jörg
- Lumenta David Benjamin
- Michelitsch Birgit
- Nischwitz Sebastian
- Puchwein Paul
- Schemmer Peter
- Singer Georg
- Smolle-Juettner Freyja-Maria
- Sucher Robert
- Till Holger
- Wolf Axel
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- Abstract:
- SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Age Distribution - administration & dosage
- Aged - administration & dosage
- COVID-19 - complications
- Cohort Studies - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Internationality - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Postoperative Complications - etiology
- Prospective Studies - administration & dosage
- SARS-CoV-2 - administration & dosage
- Sex Distribution - administration & dosage
- Venous Thromboembolism - etiology
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- COVID-19
- deep vein thrombosis
- pulmonary embolism
- SARS-CoV-2
- venous thromboembolism