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SHR Neuro Krebs Kardio Lipid

Cresti, A; Giordano, R; Koestenberger, M; Spadoni, I; Scalese, M; Limbruno, U; Falorini, S; Stefanelli, S; Picchi, A; De Sensi, F; Malandrino, A; Cantinotti, M.
Incidence and natural history of neonatal isolated ventricular septal defects: Do we know everything? A 6-year single-center Italian experience follow-up.
Congenit Heart Dis. 2018; 13(1):105-112
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Köstenberger Martin

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Plum Analytics:
Despite ventricular septal defects (VSDs) are the most common congenital heart diseases (CHDs) in the neonatal period, their incidence and natural history are still debated and their follow-up and management strategies remain controversial. Our aim was to evaluate the incidence and natural history of isolated VSDs. From January 1996 to December 2015 all neonates with a CHD suspicion were referred to the Cardiological Department of Grosseto Misericordia Hospital. Only newborns with confirmed isolated VSD were enrolled in this study and followed for 6 years. Our 343 newborns with an isolated VSD (incidence of 10.45/1000/births) account for 64% of all detected CHDs. VSDs location were as follows: muscular (73.8%), perimembranous (11.3%), inlet (1%), and outlet (0.8%). Of the located VSDs, 90% were small, 7.5% moderate, and 2.5% large, respectively. Spontaneous closure was observed in 96 (29.2%) of the VSD patients at 6-month, 198 (60.2%) at 1-year, 261 (79.3%) at 2-year, and in 302 (91.8%) at 6-year follow-up. Risk factors for defect persistence were a perimembranous location (P = .001; HR: 0.508, CI: 0.342-0.755), detection of multiple defects (P = .043; HR: 0.728, CI: 0.536-0.990), and male gender (P < .048; HR: 0.783, CI: 0.615-0.998), respectively. We here provide an incidence and natural history of neonatal isolated VSDs in a neonatal Caucasian population. These data may be useful for the development of expert consensus/standard recommendation guidelines for the follow-up and VSD management, data that are currently lacking. © 2017 Wiley Periodicals, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Disease Management -
Disease Progression -
Echocardiography - methods
Female -
Follow-Up Studies -
Heart Septal Defects, Ventricular - diagnosis
Heart Septal Defects, Ventricular - epidemiology
Humans -
Incidence -
Infant, Newborn -
Italy - epidemiology
Male -
Middle Aged -
Remission, Spontaneous -
Retrospective Studies -
Time Factors -

Find related publications in this database (Keywords)
ventricular septal defects
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