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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Adjedj, J; Xaplanteris, P; Toth, G; Ferrara, A; Pellicano, M; Ciccarelli, G; Floré, V; Barbato, E; De Bruyne, B.
Visual and Quantitative Assessment of Coronary Stenoses at Angiography Versus Fractional Flow Reserve: The Impact of Risk Factors.
Circ Cardiovasc Imaging. 2017; 10(7): [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Toth-Gayor Gabor

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Plum Analytics:
The correlation between angiographic assessment of coronary stenoses and fractional flow reserve (FFR) is weak. Whether and how risk factors impact the diagnostic accuracy of angiography is unknown. We sought to evaluate the diagnostic accuracy of angiography by visual estimate and by quantitative coronary angiography when compared with FFR and evaluate the influence of risk factors (RF) on this accuracy. In 1382 coronary stenoses (1104 patients), percent diameter stenosis by visual estimation (DSVE) and by quantitative coronary angiography (DSQCA) was compared with FFR. Patients were divided into 4 subgroups, according to the presence of RFs, and the relationship between DSVE, DSQCA, and FFR was analyzed. Overall, DSVE was significantly higher than DSQCA (P<0.0001); nonetheless, when examined by strata of DS, DSVE was significantly smaller than DSQCA in mild stenoses, although the reverse held true for severe stenoses. Compared with FFR, a large scatter was observed for both DSVE and DSQCA. When using a dichotomous FFR value of 0.80, C statistic was significantly higher for DSVE than for DSQCA (0.712 versus 0.640, respectively; P<0.001). C statistics for DSVE decreased progressively as RFs accumulated (0.776 for ≤1 RF, 0.750 for 2 RFs, 0.713 for 3 RFs and 0.627 for ≥4 RFs; P=0.0053). In addition, in diabetics, the relationship between FFR and angiographic indices was particularly weak (C statistics: 0.524 for DSVE and 0.511 for DSQCA). Overall, DSVE has a better diagnostic accuracy than DSQCA to predict the functional significance of coronary stenosis. The predictive accuracy of angiography is moderate in patients with ≤1 RFs, but weakens as RFs accumulate, especially in diabetics. © 2017 American Heart Association, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Belgium -
Cardiac Catheterization -
Coronary Angiography -
Coronary Stenosis - diagnostic imaging
Coronary Stenosis - physiopathology
Coronary Stenosis - therapy
Coronary Vessels - diagnostic imaging
Coronary Vessels - physiopathology
Databases, Factual -
Diabetic Angiopathies - diagnostic imaging
Diabetic Angiopathies - physiopathology
Female -
Fractional Flow Reserve, Myocardial -
Humans -
Male -
Middle Aged -
Predictive Value of Tests -
Prognosis -
Reproducibility of Results -
Retrospective Studies -
Risk Factors -
Severity of Illness Index -

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