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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Baykara, E; Gesierich, B; Adam, R; Tuladhar, AM; Biesbroek, JM; Koek, HL; Ropele, S; Jouvent, E; Alzheimer's Disease Neuroimaging Initiative; Chabriat, H; Ertl-Wagner, B; Ewers, M; Schmidt, R; de Leeuw, FE; Biessels, GJ; Dichgans, M; Duering, M.
A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms.
Ann Neurol. 2016; 80(4):581-592 Doi: 10.1002/ana.24758
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Co-Autor*innen der Med Uni Graz
Ropele Stefan
Schmidt Reinhold

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To establish a fully automated, robust imaging marker for cerebral small vessel disease (SVD) and related cognitive impairment that is easy to implement, reflects disease burden, and is strongly associated with processing speed, the predominantly affected cognitive domain in SVD. We developed a novel magnetic resonance imaging marker based on diffusion tensor imaging, skeletonization of white matter tracts, and histogram analysis. The marker (peak width of skeletonized mean diffusivity [PSMD]) was assessed along with conventional SVD imaging markers. We first evaluated associations with processing speed in patients with genetically defined SVD (n = 113). Next, we validated our findings in independent samples of inherited SVD (n = 57), sporadic SVD (n = 444), and memory clinic patients with SVD (n = 105). The new marker was further applied to healthy controls (n = 241) and to patients with Alzheimer's disease (n = 153). We further conducted a longitudinal analysis and interscanner reproducibility study. PSMD was associated with processing speed in all study samples with SVD (p-values between 2.8 × 10(-3) and 1.8 × 10(-10) ). PSMD explained most of the variance in processing speed (R(2) ranging from 8.8% to 46%) and consistently outperformed conventional imaging markers (white matter hyperintensity volume, lacune volume, and brain volume) in multiple regression analyses. Increases in PSMD were linked to vascular but not to neurodegenerative disease. In longitudinal analysis, PSMD captured SVD progression better than other imaging markers. PSMD is a new, fully automated, and robust imaging marker for SVD. PSMD can easily be applied to large samples and may be of great utility for both research studies and clinical use. Ann Neurol 2016;80:581-592. © 2016 American Neurological Association.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Alzheimer Disease - diagnostic imaging
Biomarkers -
Cerebral Small Vessel Diseases - complications
Cerebral Small Vessel Diseases - diagnostic imaging
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Diffusion Tensor Imaging - methods
Diffusion Tensor Imaging - standards
Female -
Humans -
Male -
Middle Aged -
Reproducibility of Results -
White Matter - diagnostic imaging
Young Adult -

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