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Kash, N; Massone, C; Fink-Puches, R; Cerroni, L.
Phenotypic Variation in Different Lesions of Mycosis Fungoides Biopsied Within a Short Period of Time From the Same Patient.
Am J Dermatopathol. 2016; 38(7):541-545 (- Case Report)
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Autor/innen der Med Uni Graz:
Cerroni Lorenzo
Fink-Puches Regina
Massone Cesare

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Phenotypic variants of mycosis fungoides (MF) include mainly the expression of cytotoxic markers by neoplastic cells (either α/β or γ/δ cytotoxic). To manage the patient properly, distinction from other cutaneous cytotoxic natural killer/T-cell lymphomas is paramount. Particularly for cutaneous γ/δ T-cell lymphoma, distinction is often based on clinicopathologic correlation (presence of tumors at first diagnosis as opposed to patches only in MF). The authors report a case of cytotoxic MF characterized by expression of TCRγ in two of three biopsies performed within a time frame of 1 week. The patient presented with patches, plaques, and 1 tumor at the time of first diagnosis; thus, distinction from cutaneous γ/δ T-cell lymphoma was not possible on clinical grounds alone. The diagnosis of MF was established, thanks to the phenotypic variations revealed by the three biopsies, with 1 lacking expression of cytotoxic proteins (TIA-1 and granzyme B) and of TCRγ. This case shows the importance to perform several biopsies in cases of cutaneous lymphoma, as morphologic and phenotypic features are variable and information gathered from a single biopsy may result in a wrong diagnosis.
Find related publications in this database (using NLM MeSH Indexing)
Antinematodal Agents - therapeutic use
Arm -
Biomarkers, Tumor - analysis
Biopsy -
Diagnosis, Differential -
Diagnostic Errors - prevention & control
Female -
Granzymes - analysis
Humans -
Immunohistochemistry -
Immunophenotyping -
Interferon alpha-2 -
Interferon-alpha - therapeutic use
Middle Aged -
Mycosis Fungoides - chemistry
Mycosis Fungoides - immunology
Mycosis Fungoides - pathology
Mycosis Fungoides - therapy
PUVA Therapy -
Phenotype -
Poly(A)-Binding Proteins - analysis
Predictive Value of Tests -
Receptors, Antigen, T-Cell, gamma-delta - analysis
Recombinant Proteins - therapeutic use
Skin Neoplasms - chemistry
Skin Neoplasms - immunology
Skin Neoplasms - pathology
Skin Neoplasms - therapy
T-Cell Intracellular Antigen-1 -
Time Factors -
Treatment Outcome -

Find related publications in this database (Keywords)
mycosis fungoides
phenotypic variation
cytotoxic lymphoma
cutaneous gamma-delta T-cell lymphoma
cutaneous T-cell lymphoma
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