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Balic, M; Lin, H; Williams, A; Datar, RH; Cote, RJ.
Progress in circulating tumor cell capture and analysis: implications for cancer management.
Expert Rev Mol Diagn. 2012; 12(3):303-312 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Balic Marija
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Abstract:
The hematogenous dissemination of cancer and development of distant metastases is the cause of nearly all cancer deaths. Detection of circulating tumor cells (CTCs) as a surrogate biomarker of metastases has gained increasing interest. There is accumulating evidence on development of novel technologies for CTC detection, their prognostic relevance and their use in therapeutic response monitoring. Many clinical trials in the early and metastatic cancer setting, particularly in breast cancer, are including CTCs in their translational research programs and as secondary end points. We summarize the progress of detection methods in the context of their clinical importance and speculate on the possibilities of wider implementation of CTCs as a diagnostic oncology tool, the likelihood that CTCs will be used as a useful biomarker, especially to monitor therapeutic response, and what may be expected from the future improvements in technologies.
Find related publications in this database (using NLM MeSH Indexing)
Breast Neoplasms - pathology Breast Neoplasms - therapy
Disease Management -
Epithelial-Mesenchymal Transition -
Female -
Humans -
Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology
Neoplastic Cells, Circulating - pathology
Neoplastic Stem Cells -
Tumor Markers, Biological - analysis Tumor Markers, Biological - metabolism

Find related publications in this database (Keywords)
cancer stem cells
characterization
circulating tumor cells
CTC
detection
DTC
enrichment
epithelial-mesenchymal transition
metastasis
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