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SHR Neuro Krebs Kardio Lipid

Pilz, S; Dobnig, H; Tomaschitz, A; Kienreich, K; Meinitzer, A; Friedl, C; Wagner, D; Piswanger-Sölkner, C; März, W; Fahrleitner-Pammer, A.
Low 25-hydroxyvitamin D is associated with increased mortality in female nursing home residents.
J Clin Endocrinol Metab. 2012; 97(4): E653-E657. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Dobnig Harald
Fahrleitner-Pammer Astrid
Friedl Claudia
Kienreich Katharina
Maerz Winfried
Meinitzer Andreas
Pilz Stefan
Piswanger-Sölkner Jutta Claudia
Tomaschitz Andreas
Wagner Doris
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Abstract:
CONTEXT: Vitamin D deficiency contributes to skeletal diseases and is highly prevalent among institutionalized elderly patients. Whether low 25-hydroxyvitamin D (25[OH]D) concentrations are an independent risk factor for mortality in these patients is, however, unclear. OBJECTIVE: We aimed to evaluate whether 25(OH)D concentrations are associated with mortality. DESIGN, SETTING, AND PARTICIPANTS: This is a prospective cohort study among elderly female patients (age >70 yr) recruited from 95 nursing homes in Austria. MAIN OUTCOME MEASURES: We calculated Cox proportional hazard ratios (HR) for all-cause mortality according to 25(OH)D quartiles. RESULTS: We examined 961 study participants (age 83.7 ± 6.1 yr). Median 25(OH)D concentration was 17.5 (interquartile range 13.7-25.5) nmol/liter, and 93% of our cohort had 25(OH)D levels below 50 nmol/liter. During a mean follow-up time of 27 ± 8 months, 284 patients died. Compared with the fourth quartile (25[OH]D >25.5 nmol/liter), the age-adjusted HR (with 95% confidence interval) was 1.49 (1.07-2.10) in the first 25(OH)D quartile (25[OH]D <14.0 nmol/liter), and this association remained significant after multivariate adjustments (HR = 1.56; 95% confidence interval = 1.01-2.40). CONCLUSIONS: This Austrian study suggests that the majority of institutionalized female patients are vitamin D deficient during winter and that there was an inverse association of 25(OH)D and mortality. These data underscore the urgent need for effective strategies for the prevention and treatment of vitamin D deficiency, in particular in the setting of nursing homes.
Find related publications in this database (using NLM MeSH Indexing)
25-Hydroxyvitamin D 2 - blood
Aged -
Aged, 80 and over -
Aging -
Aging - epidemiology
Calcifediol - blood
Cohort Studies -
Female -
Follow-Up Studies -
Frail Elderly -
Homes for the Aged -
Humans -
Mortality -
Multivariate Analysis -
Nursing Homes -
Prevalence -
Proportional Hazards Models -
Prospective Studies -
Seasons -
Vitamin D Deficiency - blood

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