Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Landgraeber, S; Quint, U; Classen, T; Totsch, M.
Senescence in cells in aseptic loosening after total hip replacement.
Acta Biomater. 2011; 7(3): 1364-1368.
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Tötsch Martin

Dimensions Citations:

Plum Analytics:
Particle-induced osteolysis is a major cause of aseptic loosening after total joint replacement. The purpose of the current study was to evaluate cellular senescence of macrophages and giant cells in patients with aseptic hip loosening by determination of SA-β-Gal (SA-β-galactosidase), a reliable and frequently used indicator of cellular senescence. The level of senescence in capsule and interface membranes was significantly higher in patients with aseptic loosening in comparison to specimens from patients without aseptic loosening. Using Spearman's rank correlation, we found that the expression of SA-β-Gal in giant cells (p=0.002) and macrophages (p=0.050) in the interface membranes correlates significantly with the degree of polyethylene debris. We speculate that the induction of DNA damage by wear particles is responsible for premature senescence. Consequently, we conclude that the form of senescence observed in this study is a "stress-induced senescence".
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Arthroplasty, Replacement, Hip -
Cell Aging -
Female -
Humans -
Immunohistochemistry -
Male -
Middle Aged -
beta-Galactosidase - metabolism

Find related publications in this database (Keywords)
Aseptic loosening
© Med Uni Graz Impressum