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SHR Neuro Krebs Kardio Lipid

Lohberger, B; Payer, M; Rinner, B; Kaltenegger, H; Wolf, E; Schallmoser, K; Strunk, D; Rohde, E; Berghold, A; Pekovits, K; Wildburger, A; Leithner, A; Windhager, R; Jakse, N.
Tri-lineage potential of intraoral tissue-derived mesenchymal stromal cells.
J Craniomaxillofac Surg. 2013; 41(2):110-118
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Autor/innen der Med Uni Graz:
Berghold Andrea
Jakse Norbert
Kaltenegger Heike
Leithner Andreas
Lohberger Birgit
Payer Michael
Pekovits Karin
Rinner Beate
Rohde Eva
Schallmoser Katharina
Strunk Dirk
Wildburger Angelika
Windhager Reinhard
Wolf Elisabeth
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Abstract:
The purpose of this study was to analyse the potential of intraoral tissues as a source of mesenchymal stromal and progenitor cells (MSPCs) for usage in future cell-based therapy models. Cells were isolated from four different tissues harvested during oral surgery intervention: (1) bone explants from the posterior maxilla, (2) bone explants from the oblique line, (3) from the mandibular periosteum, and (4) from the dental pulp. Donor sites and tissues were evaluated in terms of their accessibility, donor-site morbidity and average time period until appearance of MSPC colonies. Cell characterization was performed by flow cytometry and evaluation of in vitro osteogenic, adipogenic and chondrogenic differentiation potential. Adherent cell colonies were isolated from tissues from all sites after 4-8 days. The cells showed characteristics of MSPCs, so they were expanded up to clinical scales and demonstrated multipotency. The lowest donor-site morbidity was observed in the posterior maxilla harvests, while the highest donor-site morbidity was associated with harvests from mandibular sites. All sites seem to be potential sources of mesenchymal stromal and progenitor cells for tissue engineering approaches. Therefore, harvest morbidity and patient acceptance should affect the choice of the appropriate site. Copyright © 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adipogenesis - physiology
Adult -
Aged -
Aggrecans - analysis
Alkaline Phosphatase - analysis
Calcium - analysis
Cell Culture Techniques -
Cell Differentiation - physiology
Cell Lineage - physiology
Chondrogenesis - physiology
Dental Pulp - cytology
Humans -
Lipids - analysis
Mandible - cytology
Maxilla - cytology
Mesenchymal Stromal Cells - physiology
Middle Aged -
Multipotent Stem Cells - physiology
Osteogenesis - physiology
Periosteum - cytology
Time Factors -
Tissue and Organ Harvesting - methods
Transplant Donor Site -
Young Adult -

Find related publications in this database (Keywords)
Multipotent progenitor cells
Intraoral cell harvest
Tissue engineering
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