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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

von Bueren, AO; Friedrich, C; von Hoff, K; Kwiecien, R; Müller, K; Pietsch, T; Warmuth-Metz, M; Hau, P; Benesch, M; Kuehl, J; Kortmann, RD; Rutkowski, S.
Metastatic medulloblastoma in adults: outcome of patients treated according to the HIT2000 protocol.
Eur J Cancer. 2015; 51(16):2434-2443
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Autor/innen der Med Uni Graz:
Benesch Martin

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Due to the rarity of metastatic medulloblastoma in adults, knowledge about the efficacy and toxicity of intensified chemotherapy and radiotherapy is limited. Adults with disseminated medulloblastoma registered in the HIT2000 trial as observational patients and treated according to one of two different treatment regimens were analysed. The sandwich strategy MET-HIT2000AB4 consists of postoperative chemotherapy, hyperfractionated craniospinal radiotherapy, and maintenance chemotherapy; while the HIT'91 maintenance strategy consists of postoperative craniospinal radiotherapy, and maintenance chemotherapy. Twenty-three patients (median age: 30.7years), diagnosed from November 2001 to July 2009, and treated in 18 institutions in Germany and Austria, were eligible. The median follow-up of surviving patients was 3.99years. The 4-year event-free survival (EFS) and overall survival (OS)±standard error (SE) were 52%±12% and 91%±6%, respectively. The survival was similar in both treatment groups (HIT'91 maintenance strategy, n=9; MET-HIT2000AB4 sandwich strategy, n=14). Patients with large cell/anaplastic medulloblastoma relapsed and died (n=2; 4-year EFS/OS: 0%) and OS differed compared to patients with classic (n=11; 4-year EFS/OS: 71%/91%) and desmoplastic medulloblastoma (n=10; 4-year EFS/OS: 48%/100%), respectively (p=0.161 for EFS and p=0.033 for OS). Treatment-induced toxicities consisted mainly of neurotoxicity (50% of patients, ⩾ °II), followed by haematotoxicity and nephrotoxicity/ototoxicity. The professional outcome appeared to be negatively affected in the majority of evaluable patients (9/10). Treatment of adults with metastatic medulloblastoma according to the intensified paediatric HIT2000 protocol was feasible with acceptable toxicities. EFS rates achieved by both chemotherapeutic protocols were favourable and appear to be inferior to those obtained in older children/adolescents with metastatic disease. Copyright © 2015 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Age Factors -
Austria -
Cerebellar Neoplasms - mortality
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - therapy
Chemoradiotherapy, Adjuvant - adverse effects
Chemoradiotherapy, Adjuvant - mortality
Cranial Irradiation - adverse effects
Cranial Irradiation - mortality
Disease Progression -
Disease-Free Survival -
Dose Fractionation, Radiation -
Female -
Germany -
Humans -
Kaplan-Meier Estimate -
Maintenance Chemotherapy - adverse effects
Maintenance Chemotherapy - mortality
Male -
Medulloblastoma - mortality
Medulloblastoma - secondary
Medulloblastoma - therapy
Neurosurgical Procedures - adverse effects
Neurosurgical Procedures - mortality
Prospective Studies -
Risk Factors -
Time Factors -
Treatment Outcome -

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Brain tumour
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