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SHR Neuro Krebs Kardio Lipid

Hoenigl, M; Duettmann, W; Raggam, RB; Huber-Krassnitzer, B; Theiler, G; Seeber, K; Prueller, F; Zollner-Schwetz, I; Prattes, J; Wagner, J; Wölfler, A; Krause, R.
Impact of structured personal on-site patient education on low posaconazole plasma concentrations in patients with haematological malignancies.
Int J Antimicrob Agents. 2014; 44(2):140-144
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Düttmann Wiebke
Hönigl Martin
Krause Robert
Prattes Jürgen
Prüller Florian
Rabensteiner Jasmin
Raggam Reinhard Bernd
Theiler Georg
Wölfler Albert
Zollner-Schwetz Ines
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Abstract:
Low posaconazole plasma concentrations (PPCs) are associated with breakthrough invasive mould infections among patients with haematological malignancies. This study evaluated the influence of structured personal on-site patient education on low PPCs. The study was conducted from July 2012 to May 2013 at the Division of Hematology, Medical University Hospital of Graz (Graz, Austria). PPCs were measured in all patients with haematological malignancies receiving the drug prophylactically. Concentrations above the target of 0.5 mg/L were defined as satisfactory and those below this concentration as low. In patients with low PPCs, structured personal on-site education regarding the intake of posaconazole (e.g. intake with fatty/acid food, prevention of nausea and vomiting) was performed. In total, 258 steady-state PPCs were measured in 65 patients [median PPC 0.59 mg/L, interquartile range 0.25-0.92 mg/L; 141/258 (54.7%) satisfactory]. Diarrhoea was the strongest predictor of low PPCs in the multivariate analysis. Initial steady-state PPCs were sufficient in 29 patients and low in 36 patients. Of the 36 patients with low initial steady-state PPCs, 8 were either discharged or antifungal therapy was modified before a follow-up PPC was obtained; in the remaining 28 patients, personal on-site education was performed. In 12/28 patients (43%) the personal on-site education led to sufficient levels, whilst in 16 (57%) PPCs stayed below the target, although increasing from <0.2 mg/L to >0.3 mg/L in 6 of these patients. In conclusion, personal education appears to be a promising tool to increase low PPCs. Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Antifungal Agents - pharmacokinetics
Antifungal Agents - therapeutic use
Antifungal Agents -
Chemoprevention - methods
Cohort Studies -
Drug Monitoring -
Female -
Hematologic Neoplasms - complications
Humans -
Male -
Medication Adherence -
Middle Aged -
Mycoses - prevention & control
Patient Education as Topic -
Plasma - chemistry
Triazoles - pharmacokinetics
Triazoles - therapeutic use
Young Adult -

Find related publications in this database (Keywords)
Posaconazole
Therapeutic drug monitoring
Plasma concentrations
Haematological malignancy
Prophylaxis
Patient education
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