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Badura, A; Feierl, G; Pregartner, G; Krause, R; Grisold, AJ.
Antibiotic resistance patterns of more than 120 000 clinical Escherichia coli isolates in Southeast Austria, 1998-2013.
Clin Microbiol Infect. 2015; 21(6):569.e1-569.e7 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Badura Alexandra
Feierl Gebhard
Grisold Andrea
Krause Robert
Pregartner Gudrun
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Abstract:
Antibiotic resistance patterns of more than 120 000 clinical Escherichia coli isolates were retrospectively analysed. Isolates originated from both hospitalized patients and outpatients from the region of southeast Austria from 1998 to 2013. Except for amoxicillin/clavulanic acid, nitrofurantoin and piperacillin/tazobactam, all of the antibiotics analysed showed increasing proportions of resistant isolates over time, which were most prominent for ampicillin (from 25.4% in 1998 to 40% in 2013), cefotaxime (0.1% to 6.7%), ceftazidime (0.3% to 14.2%), ciprofloxacin (4.3% to 16.7%) and trimethoprim/sulfamethoxazole (14.6% to 24.8%). There was a marked increase in extended-spectrum β-lactamase-positive isolates (0.1% to 6.3%) starting in 2005, with male patients and hospital-related patients showing a higher increase than female patients and outpatients. Proportions of resistant isolates for most antibiotics were generally higher for male patients and hospital-related patients. Amikacin, nitrofurantoin and trimethoprim/sulfamethoxazole showed a marked increase in resistance proportions among male subjects aged 10 to 19 years which were absent for female subjects, indicating a strong modulation potential of host characteristics. Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - epidemiology
Child -
Child, Preschool -
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Cross Infection - epidemiology
Cross Infection - microbiology
Drug Resistance, Bacterial -
Escherichia coli - drug effects
Escherichia coli - enzymology
Escherichia coli - isolation & purification
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Female -
Humans -
Infant -
Infant, Newborn -
Male -
Middle Aged -
Prevalence -
Retrospective Studies -
Sex Factors -
Young Adult -
beta-Lactamases - secretion

Find related publications in this database (Keywords)
Antibiotic resistance
Austria
epidemiology
ESBL
Escherichia coli
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