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SHR Neuro Krebs Kardio Lipid

Tomaschitz, A; Verheyen, N; Gaksch, M; Meinitzer, A; Pieske, B; Kraigher-Krainer, E; Colantonio, C; März, W; Schmidt, A; Belyavskiy, E; Rus-Machan, J; van Ballegooijen, AJ; Stiegler, C; Amrein, K; Ritz, E; Fahrleitner-Pammer, A; Pilz, S.
Homoarginine in patients with primary hyperparathyroidism.
Am J Med Sci. 2015; 349(4):306-311
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Amrein Karin
Belyavskiy Evgeny
Colantonio Caterina
Fahrleitner-Pammer Astrid
Gaksch Martin
Maerz Winfried
Meinitzer Andreas
Pieske Burkert Mathias
Pieske-Kraigher Elisabeth
Pilz Stefan
Schmidt Albrecht
Tomaschitz Andreas
Verheyen Nicolas Dominik

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Plum Analytics:
Low levels of the amino acid homoarginine and parathyroid hormone (PTH) excess are both independently related to an increased risk of cardiovascular morbidity and mortality. Accumulating evidence points to a mutual interplay between homoarginine and PTH. The authors therefore aimed to investigate circulating homoarginine levels in patients with and without primary hyperparathyroidism (PHPT). The authors performed a cross-sectional analysis of serum homoarginine levels in 59 patients with mild and severe PHPT and in 92 control persons matched for age, sex and estimated glomerular filtration rate. Median PTH and serum homoarginine concentrations were 99.1 (79.7-120.2) pg/mL and 1.16 (0.95-1.66) µmol/L in patients with PHPT (79.7% female; 42.4% with normocalcemia) as compared with 45.8 (36.4-53.9) pg/mL and 1.62 (1.33-2.04) µmol/L in the control group (P < 0.001 for both), respectively. The authors observed no statistically differences between cases and controls for 25-hydroxyvitamin D [25(OH)D], serum albumin, hemoglobin, waist-to-hip ratio, C-reactive protein and NT-pBNP values. Multivariate analysis of covariance revealed that patients with PHPT had significantly lower homoarginine levels than controls (P < 0.001). This difference remained significant after adjusting for multiple confounders such as 25(OH)D, body mass index, LDL cholesterol, albumin, calcium, hemoglobin, smoking status and current antihypertensive medication. The differences of homoarginine levels persisted even after exclusion of patients with estimated glomerular filtration rate <60 mL/min (P = 0.003) and 25(OH)D levels <30 ng/mL (P = 0.001), respectively. Patients with PHPT have lower homoarginine levels compared with matched controls irrespective of age, sex, kidney function and 25(OH)D status. Further studies are needed to evaluate whether low homoarginine accounts for higher cardiovascular risk conferred by PTH excess.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Case-Control Studies -
Cross-Sectional Studies -
Female -
Homoarginine - blood
Humans -
Hyperparathyroidism, Primary - blood
Male -
Parathyroid Hormone - blood
Vitamin D - analogs & derivatives Vitamin D - blood

Find related publications in this database (Keywords)
Parathyroid hormone
Primary hyperparathyroidism
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