Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Bindea, G; Mlecnik, B; Tosolini, M; Kirilovsky, A; Waldner, M; Obenauf, AC; Angell, H; Fredriksen, T; Lafontaine, L; Berger, A; Bruneval, P; Fridman, WH; Becker, C; Pagès, F; Speicher, MR; Trajanoski, Z; Galon, J.
Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.
Immunity. 2013; 39(4):782-795 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Obenauf Anna Christina
Speicher Michael
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Abstract:
The complex interactions between tumors and their microenvironment remain to be elucidated. Combining large-scale approaches, we examined the spatio-temporal dynamics of 28 different immune cell types (immunome) infiltrating tumors. We found that the immune infiltrate composition changed at each tumor stage and that particular cells had a major impact on survival. Densities of T follicular helper (Tfh) cells and innate cells increased, whereas most T cell densities decreased along with tumor progression. The number of B cells, which are key players in the core immune network and are associated with prolonged survival, increased at a late stage and showed a dual effect on recurrence and tumor progression. The immune control relevance was demonstrated in three endoscopic orthotopic colon-cancer mouse models. Genomic instability of the chemokine CXCL13 was a mechanism associated with Tfh and B cell infiltration. CXCL13 and IL21 were pivotal factors for the Tfh/B cell axis correlating with survival. This integrative study reveals the immune landscape in human colorectal cancer and the major hallmarks of the microenvironment associated with tumor progression and recurrence.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
B-Lymphocytes - immunology
Carcinoma - genetics
Cell Movement -
Chemokine CXCL13 - genetics
Colorectal Neoplasms - genetics
Gene Expression Profiling -
Gene Expression Regulation -
Humans -
Immunity, Innate -
Interleukins - genetics
Lymphocyte Count -
Mice -
Neoplasm Recurrence, Local - genetics
Neoplasm Staging -
Protein Stability -
Survival Analysis -
T-Lymphocytes, Helper-Inducer - immunology
Tumor Microenvironment - immunology

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