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SHR Neuro Krebs Kardio Lipid

Partl, R; Regitnig, P; Tauber, G; Pötscher, M; Bjelic-Radisic, V; Kapp, KS.
Radiation-induced morphea-a rare but severe late effect of adjuvant breast irradiation : Case report and review of the literature.
Strahlenther Onkol. 2018; 194(11): 1060-1065. (- Case Report) [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Bjelic-Radisic Vesna
Kapp Karin S.
Partl Richard
Regitnig Peter
Tauber Gerlinde
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Abstract:
Radiation-induced morphea (RIM) is a circumscribed localized scleroderma that occurs most often in the breast. After an asymptomatic period of one month to several years, the symptoms (circumscribed inflammation, edema, sclerosis) often arise suddenly and cannot be clinically distinguished from a local recurrence in the form of inflammatory carcinoma. We present a case of a 74-year-old woman who developed this rare and serious local side-effect in connective tissue following neoadjuvant CDK 4/6 inhibitor abemaciclib (Verzenio®) and aromatase inhibitor anastrozole (Arimidex®) therapy and subsequent radiation therapy of the breast. Little is known about risk factors and pathogenesis of RIM. Here we describe the first case of RIM following immunotherapy. The diagnosis is based on clinical appearance and histopathological examination. Treatment should be initiated in the inflammatory stage in order to prevent or delay irreversible fibrosis and atrophy of the breast.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aminopyridines - administration & dosage
Aminopyridines - adverse effects
Anastrozole - administration & dosage
Anastrozole - adverse effects
Benzimidazoles - administration & dosage
Benzimidazoles - adverse effects
Biopsy -
Breast - pathology
Breast - radiation effects
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Combined Modality Therapy - adverse effects
Female -
Humans -
Mastectomy, Segmental -
Neoadjuvant Therapy -
Neoplasm Staging -
Radiation Injuries - etiology
Radiotherapy, Adjuvant - adverse effects
Scleroderma, Localized - etiology
Scleroderma, Localized - pathology

Find related publications in this database (Keywords)
Morphea
Radiotherapy
Scleroderma, localized
Side-effect
Breast cancer
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