Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle, MA; Herbsthofer, L; Goda, M; Granegger, B; Brcic, I; Bergovec, M; Scheipl, S; Prietl, B; El-Heliebi, A; Pichler, M; Gerger, A; Posch, F; Tomberger, M; López-García, P; Feichtinger, J; Baumgartner, C; Leithner, A; Liegl-Atzwanger, B; Szkandera, J.
Influence of tumor-infiltrating immune cells on local control rate, distant metastasis, and survival in patients with soft tissue sarcoma.
Oncoimmunology. 2021; 10(1):1896658-1896658
Doi: 10.1080/2162402X.2021.1896658
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- Führende Autor*innen der Med Uni Graz
- Smolle Maria Anna
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Baumgartner Claudia
- Bergovec Marko
- Brcic Iva
- El-Heliebi Amin
- Feichtinger Julia
- Gerger Armin
- Leithner Andreas
- Liegl-Atzwanger Bernadette
- Lopez Garcia Pablo
- Pichler Martin
- Posch Florian
- Prietl Barbara
- Scheipl Susanne
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- Abstract:
- Soft tissue sarcomas (STS) are considered non-immunogenic, although distinct entities respond to anti-tumor agents targeting the tumor microenvironment. This study's aims were to investigate relationships between tumor-infiltrating immune cells and patient/tumor-related factors, and assess their prognostic value for local recurrence (LR), distant metastasis (DM), and overall survival (OS). One-hundred-eighty-eight STS-patients (87 females [46.3%]; median age: 62.5 years) were retrospectively analyzed. Tissue microarrays (in total 1266 cores) were stained with multiplex immunohistochemistry and analyzed with multispectral imaging. Seven cell types were differentiated depending on marker profiles (CD3+, CD3+ CD4+ helper, CD3+ CD8+ cytotoxic, CD3+ CD4+ CD45RO+ helper memory, CD3+ CD8+ CD45RO+ cytotoxic memory T-cells; CD20 + B-cells; CD68+ macrophages). Correlations between phenotype abundance and variables were analyzed. Uni- and multivariate Fine&Gray and Cox-regression models were constructed to investigate prognostic variables. Model calibration was assessed with C-index. IHC-findings were validated with TCGA-SARC gene expression data of genes specific for macrophages, T- and B-cells. B-cell percentage was lower in patients older than 62.5 years (p = .013), whilst macrophage percentage was higher (p = .002). High B-cell (p = .035) and macrophage levels (p = .003) were associated with increased LR-risk in the univariate analysis. In the multivariate setting, high macrophage levels (p = .014) were associated with increased LR-risk, irrespective of margins, age, gender or B-cells. Other immune cells were not associated with outcome events. High macrophage levels were a poor prognostic factor for LR, irrespective of margins, B-cells, gender and age. Thus, anti-tumor, macrophage-targeting agents may be applied more frequently in tumors with enhanced macrophage infiltration. © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.
- Find related publications in this database (Keywords)
- Soft tissue sarcoma
- immune cell profile
- macrophages