Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schwingenschuh, P; Saifee, TA; Katschnig-Winter, P; Macerollo, A; Koegl-Wallner, M; Culea, V; Ghadery, C; Hofer, E; Pendl, T; Seiler, S; Werner, U; Franthal, S; Maurits, NM; Tijssen, MA; Schmidt, R; Rothwell, JC; Bhatia, KP; Edwards, MJ.
Validation of "laboratory-supported" criteria for functional (psychogenic) tremor.
Mov Disord. 2016; 31(4):555-562
Doi: 10.1002/mds.26525
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Schwingenschuh Petra
- Co-Autor*innen der Med Uni Graz
- Franthal Sebastian Othmar
- Ghadery Christine
- Gold Valeriu
- Hofer Edith
- Katschnig-Winter Petra
- Pendl Tamara
- Schmidt Reinhold
- Seiler Stephan
- Werner Ulrike
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- In a small group of patients, we have previously shown that a combination of electrophysiological tests was able to distinguish functional (psychogenic) tremor and organic tremor with excellent sensitivity and specificity. This study aims to validate an electrophysiological test battery as a tool to diagnose patients with functional tremor with a "laboratory-supported" level of certainty. For this prospective data collection study, we recruited 38 new patients with functional tremor (mean age 37.9 ± 24.5 years; mean disease duration 5.9 ± 9.0 years) and 73 new patients with organic tremor (mean age 55.4 ± 25.4 years; mean disease duration 15.8 ± 17.7 years). Tremor was recorded at rest, posture (with and without loading), action, while performing tapping tasks (1, 3, and 5 Hz), and while performing ballistic movements with the less-affected hand. Electrophysiological tests were performed by raters blinded to the clinical diagnosis. We calculated a sum score for all performed tests (maximum of 10 points) and used a previously suggested cut-off score of 3 points for a diagnosis of laboratory-supported functional tremor. We demonstrated good interrater reliability and test-retest reliability. Patients with functional tremor had a higher average score on the test battery when compared with patients with organic tremor (3.6 ± 1.4 points vs 1.0 ± 0.8 points; P < .001), and the predefined cut-off score for laboratory-supported functional tremor yielded a test sensitivity of 89.5% and a specificity of 95.9%. We now propose this test battery as the basis of laboratory-supported criteria for the diagnosis of functional tremor, and we encourage its use in clinical and research practice. © 2016 International Parkinson and Movement Disorder Society.
- Find related publications in this database (using NLM MeSH Indexing)
- Accelerometry - methods
- Accelerometry - standards
- Adult -
- Aged -
- Electromyography - methods
- Electromyography - standards
- Evidence-Based Medicine -
- Female -
- Follow-Up Studies -
- Humans -
- Male -
- Middle Aged -
- Neurologic Examination - methods
- Neurologic Examination - standards
- Psychophysiologic Disorders - diagnosis
- Psychophysiologic Disorders - physiopathology
- Reproducibility of Results -
- Single-Blind Method -
- Tremor - diagnosis
- Tremor - physiopathology
- Find related publications in this database (Keywords)
- Psychogenic
- functional
- diagnostic criteria
- electrophysiological criteria