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Regauer, S; Liegl, B; Reich, O; Beham-Schmid, C.
Vasculitis in lichen sclerosus: an under recognized feature?
Histopathology. 2004; 45(3):237-244 Doi: 10.1111/j.1365-2559.2004.01929.x
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Führende Autor*innen der Med Uni Graz
Regauer Sigrid
Co-Autor*innen der Med Uni Graz
Beham-Schmid Christine
Liegl-Atzwanger Bernadette
Reich Olaf

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AIMS: To analyse 90 vulvar and 72 penile cases of lichen sclerosus (LS) on haematoxylin and eosin sections for vascular changes and the vascular infiltrates immunohistochemically with antibodies to T cells, B cells and antigen-presenting dendritic cells. LS is a skin disease of presumed autoimmune origin. Autoimmune diseases are mediated by lymphocytes which occasionally produce a lymphocytic vasculitis. METHODS AND RESULTS: Three types of lymphocytic infiltrates were identified: (i) perivascular lymphocytic infiltrates without damage to vessel walls; (ii) lymphocytic vasculitis in three forms: (a) concentric lymphohistiocytic infiltrates with lamination of the adventitia by basement membrane material which was typical for penile LS; (b) lymphocytic vasculitis with dense perivascular lymphocytic cuffing with occasional fibrin deposition in vessel walls and subendothelial lymphocyte infiltration, quite common in vulvar LS; and (c) intramural lymphocytic infiltrates in large muscular vessels; (iii) leukocytoclastic vasculitis in LS was exceptionally rare. In lymphocytic vasculitis, CD20+ B cells, CD4+ T cells and dendritic cells were the principal infiltrating cells. CONCLUSIONS: Dendritic cells capture (foreign) antigens after entry into the affected tissues and initiate immune responses acting as a matrix on which antigen-specific T and B cells interact. The described vascular features are indicative of antigen-mediated vasculitic changes in LS.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Antigens, CD20 - analysis
Antigens, CD4 - analysis
Antigens, CD8 - analysis
Female - analysis
Granzymes - analysis
Humans - analysis
Immunohistochemistry - analysis
Lichen Sclerosus et Atrophicus - metabolism
Male - metabolism
Middle Aged - metabolism
Serine Endopeptidases - analysis
Vasculitis - metabolism

Find related publications in this database (Keywords)
autoimmune disease
dendritic cells
immune response
leukocytoclastic vasculitis
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