Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jahn, SW; Jost, PJ.
Challenges in integrating molecular profiles into clinical cancer care
MEMO-MAG EUR MED ONC. 2022;
Doi: 10.1007/s12254-022-00838-1
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Jahn Stephan
- Jost Philipp
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- Abstract:
- Profiling of malignancies with next-generation sequencing (NGS) is now routine in clinical practice. While many cases of approved targeted therapies are straightforward based on well-characterized alterations, applying large NGS multigene panels to therapeutic use is frequently challenging. In this article, variant interpretation, therapy matching, and final treatment selection challenges are discussed.
- Find related publications in this database (Keywords)
- Next-generation sequencing application
- Variant annotation
- Therapy matching
- Challenges
- Clinical tiering