Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Bengesser, SA; Hohenberger, H; Tropper, B; Dalkner, N; Birner, A; Fellendorf, FT; Platzer, M; Rieger, A; Maget, A; Hamm, C; Queissner, R; Pilz, R; Bauer, K; Lenger, M; Mörkl, S; Wagner-Skacel, J; Kapfhammer, HP; Meier-Allard, N; Stracke, A; Holasek, SJ; Murphy, L; Reininghaus, EZ.
Gene expression analysis of MAOA and the clock gene ARNTL in individuals with bipolar disorder compared to healthy controls.
World J Biol Psychiatry. 2022; 23(4):287-294 Doi: 10.1080/15622975.2021.1973816
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Bengesser Susanne
Dalkner Nina
Co-Autor*innen der Med Uni Graz
Bauer Konstantin
Birner Armin
Fellendorf Frederike
Hamm Carlo
Holasek Sandra Johanna
Kapfhammer Hans-Peter
Lenger Melanie
Maget Alexander
Meier-Allard Nathalie
Mörkl Sabrina
Pilz Rene
Platzer Martina
Queissner Robert
Reininghaus Eva
Rieger Alexandra
Stracke Anika
Wagner-Skacel Jolana

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

INTRODUCTION: Circadian rhythms are associated with bipolar disorder (BD). This cross-sectional study aimed at investigating ARNTL and MAOA gene expression differences (1) between individuals with BD and controls, (2) between affective episodes, and (3) the relationship between ARNTL and MAOA expression. METHODS: ARNTL and MAOA gene expression in peripheral mononuclear blood cells were analysed from fasting blood samples (BD n =  81, controls n = 54) with quantitative real-time PCR operating on TaqMan® assays (normalised to 18S RNA expression). ANCOVAs corrected for age, sex, body mass index, and medication was used to evaluate expression differences and correlation analyses for the relation between ARNTL and MAOA expression. RESULTS: ARNTL gene expression differed between affective episodes (F(2,78) = 3.198, p = 0.047, Partial Eta2= 0.083), but not between BD and controls (n.s.). ARNTL and MAOA expression correlated positively in BD (r = 0.704, p < 0.001) and in controls (r = 0.932, p < 0.001). MAOA expression differed neither between BD and controls nor between affective episodes (n.s.). DISCUSSION: Clock gene expression changes were observed in different affective states of BD. More precisely, ARNTL gene expression was significantly higher in euthymia than in depression. ARNTL and MAOA gene expression correlated significantly in BD and in controls, which emphasises the strong concatenation between circadian rhythms and neurotransmitter breakdown.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
ARNTL Transcription Factors - genetics
Bipolar Disorder - genetics
Circadian Rhythm - genetics
Cross-Sectional Studies - administration & dosage
Gene Expression - administration & dosage
Monoamine Oxidase - genetics

Find related publications in this database (Keywords)
Bipolar disorder
clock genes
© Med Uni Graz Impressum