Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bengesser, SA; Hohenberger, H; Tropper, B; Dalkner, N; Birner, A; Fellendorf, FT; Platzer, M; Rieger, A; Maget, A; Hamm, C; Queissner, R; Pilz, R; Bauer, K; Lenger, M; Mörkl, S; Wagner-Skacel, J; Kapfhammer, HP; Meier-Allard, N; Stracke, A; Holasek, SJ; Murphy, L; Reininghaus, EZ.
Gene expression analysis of MAOA and the clock gene ARNTL in individuals with bipolar disorder compared to healthy controls.
World J Biol Psychiatry. 2022; 23(4):287-294
Doi: 10.1080/15622975.2021.1973816
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- Führende Autor*innen der Med Uni Graz
- Bengesser Susanne
- Dalkner Nina
- Co-Autor*innen der Med Uni Graz
- Bauer Konstantin
- Birner Armin
- Fellendorf Frederike
- Hamm Carlo
- Holasek Sandra Johanna
- Kapfhammer Hans-Peter
- Lenger Melanie
- Maget Alexander
- Meier-Allard Nathalie
- Mörkl Sabrina
- Pilz Rene
- Platzer Martina
- Queissner Robert
- Reininghaus Eva
- Rieger Alexandra
- Stracke Anika
- Wagner-Skacel Jolana
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- Abstract:
- INTRODUCTION: Circadian rhythms are associated with bipolar disorder (BD). This cross-sectional study aimed at investigating ARNTL and MAOA gene expression differences (1) between individuals with BD and controls, (2) between affective episodes, and (3) the relationship between ARNTL and MAOA expression. METHODS: ARNTL and MAOA gene expression in peripheral mononuclear blood cells were analysed from fasting blood samples (BD n = 81, controls n = 54) with quantitative real-time PCR operating on TaqMan® assays (normalised to 18S RNA expression). ANCOVAs corrected for age, sex, body mass index, and medication was used to evaluate expression differences and correlation analyses for the relation between ARNTL and MAOA expression. RESULTS: ARNTL gene expression differed between affective episodes (F(2,78) = 3.198, p = 0.047, Partial Eta2= 0.083), but not between BD and controls (n.s.). ARNTL and MAOA expression correlated positively in BD (r = 0.704, p < 0.001) and in controls (r = 0.932, p < 0.001). MAOA expression differed neither between BD and controls nor between affective episodes (n.s.). DISCUSSION: Clock gene expression changes were observed in different affective states of BD. More precisely, ARNTL gene expression was significantly higher in euthymia than in depression. ARNTL and MAOA gene expression correlated significantly in BD and in controls, which emphasises the strong concatenation between circadian rhythms and neurotransmitter breakdown.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- ARNTL Transcription Factors - genetics
- Bipolar Disorder - genetics
- Circadian Rhythm - genetics
- Cross-Sectional Studies - administration & dosage
- Gene Expression - administration & dosage
- Monoamine Oxidase - genetics
- Find related publications in this database (Keywords)
- Bipolar disorder
- clock genes
- ARNTL
- MAOA