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Kvietkauskas, M; Leber, B; Strupas, K; Stiegler, P; Schemmer, P.
Machine Perfusion of Extended Criteria Donor Organs: Immunological Aspects.
Front Immunol. 2020; 11: 192-192. Doi: 10.3389/fimmu.2020.00192 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Schemmer Peter
Co-Autor*innen der Med Uni Graz
Leber Bettina
Stiegler Philipp

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Due to higher vulnerability and immunogenicity of extended criteria donor (ECD) organs used for organ transplantation (Tx), the discovery of new treatment strategies, involving tissue allorecognition pathways, is important. The implementation of machine perfusion (MP) led to improved estimation of the organ quality and introduced the possibility to achieve graft reconditioning prior to Tx. A significant number of experimental and clinical trials demonstrated increasing support for MP as a promising method of ECD organ preservation compared to classical static cold storage. MP reduced ischemia-reperfusion injury resulting in the protection from inadequate activation of innate immunity. However, there are no general agreements on MP protocols, and clinical application is limited. The objective of this comprehensive review is to summarize literature on immunological effects of MP of ECD organs based on experimental studies and clinical trials. Copyright © 2020 Kvietkauskas, Leber, Strupas, Stiegler and Schemmer.

Find related publications in this database (Keywords)
extended criteria donors
immunological rejection
machine perfusion
marginal organs
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