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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pinter, D; Enzinger, C; Gattringer, T; Eppinger, S; Niederkorn, K; Horner, S; Fandler, S; Kneihsl, M; Krenn, K; Bachmaier, G; Fazekas, F.
Prevalence and short-term changes of cognitive dysfunction in young ischaemic stroke patients.
Eur J Neurol. 2019; 26(5):727-732 Doi: 10.1111/ene.13879 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Pinter Daniela Theresia
Co-Autor*innen der Med Uni Graz
Bachmaier Gerhard
Enzinger Christian
Eppinger Sebastian
Fandler-Höfler Simon
Fazekas Franz
Gattringer Thomas
Horner Susanna
Kneihsl Markus
Niederkorn Kurt

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Information on the prevalence and course of post-stroke cognitive impairment in young stroke patients is limited. The aim was to assess a consecutive sample of acute young ischaemic stroke patients (18-55 years) for the presence and development of neuropsychological deficits. Patients prospectively underwent a comprehensive clinical and cognitive assessment, examining general cognitive function, processing speed, attention, flexibility/executive function and word fluency within the first 3 weeks after hospital admission (median assessment at day 6) and at a 3 months' follow-up (FU). Cognitive dysfunction was defined in comparison to age-standardized published norms. At baseline (N = 114), deficits were highly prevalent in processing speed (56.0%), flexibility/executive function (49.5%), attention (46.4%) and general cognitive function (42.1%). These frequencies were comparable for those with FU assessment (N = 87). In most domains, cognitive performance improved within 3 months, except for word fluency. However, in about one-third of patients, cognitive deficits (as defined by 1.5 standard deviations below the standardized mean) were still present 3 months after stroke. At FU, 44.0% were impaired in the domain flexibility/executive function, 35.0% in processing speed and 30.0% in attention. The high prevalence of cognitive deficits in acute young patients with ischaemic stroke highlights the importance of early post-stroke cognitive assessment to capture a patient's dysfunction in a comprehensive manner and to offer adequate rehabilitation. The role of factors which promote neuropsychological deficits needs further exploration. © 2018 The Authors European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.

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