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Kahn, J; Wagner, D; Homfeld, N; Müller, H; Kniepeiss, D; Schemmer, P.
Both sarcopenia and frailty determine suitability of patients for liver transplantation-A systematic review and meta-analysis of the literature.
Clin Transplant. 2018; 32(4):e13226-e13226 Doi: 10.1111/ctr.13226
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Führende Autor*innen der Med Uni Graz
Kahn Judith
Schemmer Peter
Co-Autor*innen der Med Uni Graz
Kniepeiss Daniela
Koter Nicole
Müller Helmut
Wagner Doris

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Liver grafts are allocated based on both urgency and utility. Due to a tremendous shortage of suitable organs for liver transplantation (LT), a careful selection of suitable recipients is of utmost importance. While the sickest first principle for organ allocation based on MELD score goes along with poor utility, other parameters reflecting the general health condition like frailty and sarcopenia might be essential to detect suitable patients for the waiting list. Thus, this study was designed to evaluate both frailty and sarcopenia in LT. A systematic review of the literature on sarcopenia and frailty measurements in liver transplant recipients was performed. Thirteen of 238 studies were selected for full paper review. Six of the studies investigating the impact of frailty on waitlist mortality were subjected to a meta-analysis. Despite the different methodologies to assess sarcopenia, reports showed that sarcopenia was highly related to waitlist mortality with a sum of all that highly favored negative outcome in case of sarcopenia. The existing literature clearly underlines that frailty and sarcopenia are important to determine in LT candidates. One unique index for transplant candidates reflecting frailty should be developed and be used as a standard in all transplant centers to facilitate comparability. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Find related publications in this database (Keywords)
liver transplantation
muscle wasting
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