Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schwab, C; Wackernagel, W; Grinninger, P; Mayer, C; Schwab, K; Langmann, G; Richtig, E; Wedrich, A; Hofmann-Wellenhof, R; Zalaudek, I.
A Unifying Concept of Uveal Pigment Cell Distribution and Dissemination Based on an Animal Model: Insights into Ocular Melanogenesis.
Cells Tissues Organs. 2016; 201(3):232-8
Doi: 10.1159/000443877
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Schwab Christoph
- Co-Autor*innen der Med Uni Graz
- Hofmann-Wellenhof Rainer
- Langmann Gerald
- Mayer-Xanthaki Christoph Fidel
- Richtig Erika
- Schwab Katharina
- Wackernagel Werner
- Wedrich Andreas
- Zalaudek Iris
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- Abstract:
- Pigmented cells are derived from neural crest cells, which migrate along the peripheral nerve sheets into their specific final region. During their migration, cells progressively acquire pigment-producing capabilities, maturation, and the shape of melanocytes. These insights, along with specific clinical characteristics of melanocytic nevi, have led to new concepts of cutaneous, periocular, and iris nevogenesis. To further elucidate the specific ocular embryogenic melanoblast distribution and dissemination - that could explain the distinct distribution of uveal melanocytic neoplasms - we investigated the ocular pigmentation of dogs affected by a specific mutation called Merle, which results in either pigment- (wild type) or non-pigment- (mutated type) producing cells. Based on our observations, we propose a unifying concept of uveal pigment cell distribution and dissemination, which postulates melanoblast migration and maturation following the trigeminal V1 branch and, later, their entrance into the eye along the ciliary nerves and their finest iris branches. Our concept provides an explanation not only for the specific distribution of ocular melanocytic lesions, including uveal and iris nevi, but also for the different locations depending on the metastatic potential of the ocular melanoma. Though speculative, the higher metastatic potential of posterior uveal melanomas compared to iris melanomas may be related to a less differentiated stage in the maturation of migrating melanocytes in the posterior segment compared to the anterior segment of the eye. However, there is a need of further studies focusing on cell differentiation markers of melanocytes at different locations in the eye.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Cell Movement - administration & dosage
- Disease Models, Animal - administration & dosage
- Dogs - administration & dosage
- Melanocytes - pathology
- Melanoma - pathology
- Uvea - pathology
- Uveal Neoplasms - pathology
- Find related publications in this database (Keywords)
- Uveal melanocytes
- Uveal melanoma
- Uveal nevi
- Embryology
- Development
- Neoplasia