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Langmann, G; Wackernagel, W; Stücklschweiger, G; Feichtinger, K; Papaefthymiou, G; Faulborn, J.
Dose-volume histogram regression analysis of uveal melanomas after single fraction gamma knife radiosurgery].
Ophthalmologe. 2004; 101(11):1111-1119 Doi: 10.1007/s00347-003-0984-y
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Führende Autor*innen der Med Uni Graz
Langmann Gerald
Co-Autor*innen der Med Uni Graz
Dominikus Karlheinz
Feichtinger Karlheinz
Papaefthymiou Georgios
Wackernagel Werner

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To evaluate tumor regression and sequelae in 30 uveal melanomas treated with Gamma Knife radiosurgery between 1992 and 1995 at the Gamma Knife center in Graz. A total of 30 uveal and ciliary body melanomas were treated with a single fraction of the Gamma Knife. The mean marginal dose was 52.1 Gy, (median 50 Gy). Of the tumors, 15 were large (higher than 8 mm), 14 were medium sized (3-8 mm) and one was a small melanoma (<3 mm). Among them were 6 juxtapapillary, 10 (juxta-) maculary melanomas, 5 tumors located in the midperiphery and 9 ciliary body melanomas. Dose-volume histogram analysis. After a maximum follow up of 9 years and 7 months, 8 tumors regressed into a scar, 17 tumors into a residual prominence between 50% and 80% of the initial tumor height, 3 tumors showed no change and in 2 patients recurrence was obvious. Sequelae were classified as mild (in 3 patients), moderate (3), severe (5) and very severe (19). Significant factors for the development of severe sequelae were the tumor volume and the marginal dose, the mean dose proved to be more important than the marginal dose and the irradiated volume more important than the selective critical dose.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Dose Fractionation -
Dose-Response Relationship, Radiation -
Female -
Female - epidemiology
Humans -
Male -
Melanoma - epidemiology Melanoma - pathology Melanoma - radiotherapy
Middle Aged -
Neoplasm Recurrence, Local - epidemiology
Radiosurgery - methods Radiosurgery - statistics & numerical data
Severity of Illness Index -
Statistics as Topic -
Treatment Outcome -
Uveal Neoplasms - epidemiology Uveal Neoplasms - pathology Uveal Neoplasms - radiotherapy

Find related publications in this database (Keywords)
dose-volume histogram
Gamma Knife
uveal melanoma
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