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Fandler-Höfler, S; Ropele, S; Gattringer, T; Haidegger, M; Pinter, D; Kneihsl, M; Korompoki, E; Montaner, J; Caso, V; Ringleb, PA; Sibon, I; Halse, O; Harvey, K; Fießler, C; Wolfe, CDA; Heuschmann, PU; Veltkamp, R; Enzinger, C, , PRESTIGE-AF, Consortium.
Neuroimaging Markers Associated With Recurrent Stroke in Intracerebral Hemorrhage and Atrial Fibrillation: Secondary Analysis of PRESTIGE-AF.
Neurology. 2025; 105(11): e214386 Doi: 10.1212/WNL.0000000000214386 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Enzinger Christian
Fandler-Höfler Simon
Co-Autor*innen der Med Uni Graz
Gattringer Thomas
Haidegger Melanie
Kneihsl Markus
Pinter Daniela Theresia
Ropele Stefan
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Abstract:
BACKGROUND AND OBJECTIVES: Anticoagulation in patients with intracerebral hemorrhage (ICH) and atrial fibrillation reduces the risk of ischemic stroke (IS), but also potentially causes an excess risk of recurrent ICH. In this context, we assessed the role of neuroimaging in identifying patients with particular susceptibility to IS or ICH, potentially allowing for individualized risk stratification. METHODS: In PRESTIGE-AF, a prospective, randomized clinical trial conducted across 75 hospitals in 6 European countries, participants with spontaneous ICH and atrial fibrillation were randomized to treatment with direct oral anticoagulants or no anticoagulation. Within a prespecified imaging subanalysis, we centrally assessed brain CT and MRI scans at baseline using established scales and definitions. We performed Cox regression analyses to investigate associations of neuroimaging findings with recurrent ICH and IS. RESULTS: PRESTIGE-AF included 319 patients, and 313 had neuroimaging of sufficient quality (median age 79 years, 35.5% female). MRI was available in 170 patients (54.3%). During a median follow-up of 1.4 years, 13 patients had recurrent ICH and 22 patients had IS. ICH recurrence was not associated with lobar vs nonlobar hematoma location or the overall category of probable cerebral amyloid angiopathy (p > 0.2). However, there was an increased risk of recurrent ICH in patients with cortical superficial siderosis (hazard ratio [HR] 7.7, 95% CI 1.4-42.2) and chronic intracerebral macrohemorrhages on MRI (HR 9.1, 95% CI 1.8-46.8). Patients with nonlobar ICH were at increased risk of IS (HR 9.1, 95% CI 1.2-67.7). DISCUSSION: Neuroimaging contributes to the identification of patients with ICH and atrial fibrillation at particularly high risk of recurrent ICH or IS, emphasizing its role in clinical decision making. MRI allows for the assessment of relevant neuroimaging markers that can aid the risk assessment in affected patients. Major study limitations include the modest number of outcome events, with confirmation of our findings needed in larger collaborations. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov NCT03996772; first submitted June 21, 2019; first patient enrolled: May 31, 2019; available at clinicaltrials.gov/study/NCT03996772.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Atrial Fibrillation - complications, drug therapy, diagnostic imaging
Female - administration & dosage
Male - administration & dosage
Aged - administration & dosage
Cerebral Hemorrhage - diagnostic imaging, complications, epidemiology
Recurrence - administration & dosage
Aged, 80 and over - administration & dosage
Magnetic Resonance Imaging - administration & dosage
Neuroimaging - methods
Anticoagulants - therapeutic use
Middle Aged - administration & dosage
Prospective Studies - administration & dosage
Ischemic Stroke - diagnostic imaging, epidemiology
Tomography, X-Ray Computed - administration & dosage
Stroke - diagnostic imaging

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