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Holzer, M; Gruden, E; Curcic, S; Cvirn, G; Marsche, G.
ApoC3 Attenuates Platelet Activation Through GPIIb/IIIa Receptor Interaction.
Cells. 2025; 14(18): Doi: 10.3390/cells14181411 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Holzer Michael
Marsche Gunther
Co-Autor*innen der Med Uni Graz
Curcic Sanja
Cvirn Gerhard
Gruden Eva
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Abstract:
Apolipoprotein C3 (apoC3) is a key regulator of triglyceride metabolism and has emerged as a potential therapeutic target for reducing the risk of cardiovascular disease. However, its broader physiological functions are not fully understood. This study investigates the role of apoC3 in platelet function and thrombus formation. Interestingly, human apoC3 was found to rapidly inhibit platelet activation over the tested concentration range of 0.1-10 µg/mL, with significant effects observed at low concentrations and brief pre-incubation times (from 1 min). At a concentration of 10 µg/mL, apoC3 suppressed platelet activation by approximately 70% in response to ADP and by approximately 40% in response to collagen stimulation. Depleting apoC3 from human serum enhanced platelet aggregation by more than 25 % (1.28 ± 0.19 vs. vehicle), indicating an endogenous regulatory function of apoC3. Mechanistically, apoC3 binding to platelets reduced both GPIIb/IIIa activation and P-selectin expression by around 20%. ApoC3 binding to platelets increased when platelets were activated by ADP and was partially mediated by GPIIb/IIIa, implicating this integrin as a functionally relevant receptor. Taken together, these findings reveal a novel link between apoC3 and platelet biology with potential implications for thrombotic risk and vascular homeostasis.
Find related publications in this database (using NLM MeSH Indexing)
Apolipoprotein C-III - metabolism, pharmacology
Humans - administration & dosage
Platelet Activation - drug effects
Platelet Glycoprotein GPIIb-IIIa Complex - metabolism
Blood Platelets - metabolism, drug effects
Platelet Aggregation - drug effects
P-Selectin - metabolism
Protein Binding - administration & dosage
Adenosine Diphosphate - pharmacology

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