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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Silbernagel, G; Higbie, H; Meininger, T; Lemen, D; Li, HX; Chen, YQ; Wen, Y; Zhen, EY; Qian, YW; Korovianskaia, P; Trampisch, HJ; Scharnagl, H; Marz, W; Stang, A; Erbel, R; Konrad, RJ; Schmidt, B.
Associations of ANGPTL proteins and complexes with progression of coronary artery calcification and coronary events
ATHEROSCLEROSIS. 2025; 409: 120485 Doi: 10.1016/j.atherosclerosis.2025.120485
Web of Science PubMed FullText FullText_MUG

 

Autor*innen der Med Uni Graz:
Korovianskaia Polina
März Winfried
Scharnagl Hubert
Silbernagel Günther
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Abstract:
Background and aims: Angiopoietin-like protein 8 (ANGPTL8) forms complexes with ANGPTL3 and ANGPTL4 to regulate lipoprotein lipase (LPL) activity, and decreased LPL activity is an established cardiovascular risk factor. Serum levels of ANGPTL4/8 and C-terminal domain-containing ANGPTL4 (CD-ANGPTL4) are positively associated with cardiovascular death, however, the underlying mechanisms remain incompletely understood. The present study investigated relationships of ANGPTL3, ANGPTL3/8, CD-ANGPTL4, and ANGPTL4/8 with coronary artery calcification (CAC) progression (using Agatston scores) and incident coronary events. Methods: ANGPTL3, ANGPTL3/8, CD-ANGPTL4, and ANGPTL4/8, were measured using dedicated immunoassays in participants of the Heinz Nixdorf Recall (HNR) study, an unselected, population-based cohort of subjects free from cardiovascular disease at baseline. CAC measurements were performed at baseline and after 5 years in 2887 participants, and there was follow-up for coronary events (median duration 18.8 years). Results: Median Agatston scores increased over 5 years from 6.70 (t0) to 24.75 (t1), and 315 participants experienced a coronary event. Concentrations of ANGPTL3 and ANGPTL3/8 were not associated with Agatston score progression. ANGPTL3 was associated with incident coronary events, whereas ANGPTL3/8 was not. In contrast, CD-ANGPTL4 and ANGPTL4/8 were positively associated with both Agatston score progression and incident coronary events. Conclusions: Associations of ANGPTL3 and ANGPTL3/8 with coronary atherosclerosis progression and incident coronary events were inconsistent, while CD-ANGPTL4 and ANGPTL4/8 were associated with both coronary atherosclerosis progression and incident coronary events. Associations of ANGPTL4/8 and CD-ANGPTL4 with cardiovascular events may reflect progression of coronary atherosclerosis conferred by diabetes, inflammation, or the potential intrinsic effects of CD-ANGPTL4 and ANGPTL4/8.

Find related publications in this database (Keywords)
ANGPTL4/8
CD-ANGPTL4
Coronary event
Coronary artery calcification (CAC)
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