Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Masi, S; Dalpiaz, H; Piludu, S; Piani, F; Fiorini, G; Borghi, C.
New strategies for the treatment of hyperkalemia.
Eur J Intern Med. 2025; 132:18-26 Doi: 10.1016/j.ejim.2024.10.016
PubMed FullText FullText_MUG

 

Autor*innen der Med Uni Graz:
Piani Federica
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
Renin-angiotensin-aldosterone system inhibitors (RAASi) and mineralocorticoid receptor antagonists (MRAs) are key drugs in the management of patients with cardiovascular diseases (CVD), particularly those with hypertension, diabetes, chronic kidney disease and heart failure (HF), given their demonstrated effectiveness in reducing the risk of both surrogate and hard endpoints. Despite their positive impact on the outcome, patients with RAASi and MRAs are particularly vulnerable to hyperkalaemia, with approximately 50 % of these individuals experiencing two or more recurrences annually. The common practice of reducing the dose or discontinuing the treatment with RAASi and MRAs in conditions of hyperkalaemia results in suboptimal management of these patients, with a potential impact on their mortality and morbidity risk. Recent guidelines from cardiovascular and renal international societies increasingly recognize the need for alternative strategies to manage the risk of hyperkalaemia, allowing the continuation of RAASi and MRA therapies. In this review, we summarise the new potential options available to manage hyperkalaemia in patients with CVD and the recommendations of the most recent guidelines on the topic.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Hyperkalemia - drug therapy, chemically induced
Mineralocorticoid Receptor Antagonists - therapeutic use, adverse effects
Cardiovascular Diseases - drug therapy, complications
Angiotensin Receptor Antagonists - therapeutic use, adverse effects
Practice Guidelines as Topic - administration & dosage
Renin-Angiotensin System - drug effects
Angiotensin-Converting Enzyme Inhibitors - therapeutic use

© Med Uni Graz • Impressum