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SHR Neuro Cancer Cardio Lipid Metab Microb

Raftopoulou, S; Valadez-Cosmes, P; Mihalic, ZN; Schicho, R; Kargl, J.
Tumor-Mediated Neutrophil Polarization and Therapeutic Implications.
Int J Mol Sci. 2022; 23(6): Doi: 10.3390/ijms23063218 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Leading authors Med Uni Graz
Kargl Julia
Raftopoulou Sofia
Co-authors Med Uni Graz
Juvan Zala Nikita
Schicho Rudolf
Valadez Cosmes Paulina
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Abstract:
Neutrophils are immune cells with reported phenotypic and functional plasticity. Tumor-associated neutrophils display many roles during cancer progression. Several tumor microenvironment (TME)-derived factors orchestrate neutrophil release from the bone marrow, recruitment and functional polarization, while simultaneously neutrophils are active stimulators of the TME by secreting factors that affect immune interactions and subsequently tumor progression. Successful immunotherapies for many cancer types and stages depend on the targeting of tumor-infiltrating lymphocytes. Neutrophils impact the success of immunotherapies, such as immune checkpoint blockade therapies, by displaying lymphocyte suppressive properties. The identification and characterization of distinct neutrophil subpopulations or polarization states with pro- and antitumor phenotypes and the identification of the major TME-derived factors of neutrophil polarization would allow us to harness the full potential of neutrophils as complementary targets in anticancer precision therapies.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Immunotherapy - administration & dosage
Lymphocytes, Tumor-Infiltrating - pathology
Neoplasms - pathology
Neutrophils - administration & dosage
Tumor Microenvironment - administration & dosage

Find related publications in this database (Keywords)
tumor microenvironment
immune cells
neutrophils
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