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SHR Neuro Cancer Cardio Lipid Metab Microb

Valadez-Cosmes, P; Raftopoulou, S; Mihalic, ZN; Marsche, G; Kargl, J.
Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target.
Pharmacol Ther. 2022; 236:108052 Doi: 10.1016/j.pharmthera.2021.108052
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Leading authors Med Uni Graz
Kargl Julia
Valadez Cosmes Paulina
Co-authors Med Uni Graz
Juvan Zala Nikita
Marsche Gunther
Raftopoulou Sofia
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Abstract:
Myeloperoxidase is a heme-peroxidase which makes up approximately 5% of the total dry cell weight of neutrophils where it is predominantly found in the primary (azurophilic) granules. Other cell types, such as monocytes and certain macrophage subpopulations also contain myeloperoxidase, but to a much lesser extent. Initially, the function of myeloperoxidase had been mainly associated with its ability as a catalyzer of reactive oxidants that help to clear pathogens. However, over the past years non-canonical functions of myeloperoxidase have been described both in health and disease. Attention has been specially focused on inflammatory diseases, in which an exacerbate infiltration of leukocytes can favor a poorly-controlled production and release of myeloperoxidase and its oxidants. There is compelling evidence that myeloperoxidase derived oxidants contribute to tissue damage and the development and propagation of acute and chronic vascular inflammation. Recently, neutrophils have attracted much attention within the large diversity of innate immune cells that are part of the tumor microenvironment. In particular, neutrophil-derived myeloperoxidase may play an important role in cancer development and progression. This review article aims to provide a comprehensive overview of the roles of myeloperoxidase in the development and progression of cancer. We propose future research approaches and explore prospects of inhibiting myeloperoxidase as a strategy to fight against cancer.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Inflammation - metabolism
Neoplasms - drug therapy, metabolism
Neutrophils - administration & dosage
Oxidants - metabolism
Peroxidase - metabolism
Tumor Microenvironment - administration & dosage

Find related publications in this database (Keywords)
Myeloperoxidase
Neutrophils
Tumor microenvironment
Hypochlorous acid
Cancer
Inflammation
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