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Windisch, M; Hutter-Paier, B; Grygar, E; Doppler, E; Moessler, H.
N-PEP-12--a novel peptide compound that protects cortical neurons in culture against different age and disease associated lesions.
J Neural Transm. 2005; 112(10): 1331-1343. Doi: 10.1007/s00702-005-0283-7
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Co-Autor*innen der Med Uni Graz
Grygar Elisabeth Lucia
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Abstract:
The neuroprotective potency of N-PEP-12, a novel, proprietary compound consisting of biopeptides and amino acids was investigated. Lesion models have been applied in neuronal cultures of embryonic chicken cortex, pre-treated with N-PEP-12 from the first day onwards. On day 8 in vitro neurons were lesioned and cell viability was measured 24 and 48 hours later. To simulate acute brain ischemia, cytotoxic hypoxia was induced by sodium cyanide or by iodoacetate and excitotoxicity by L-glutamate. Ionomycin for up to 48 hours induced calcium overload. The cytoskeleton was disrupted by addition of colchicine. N-PEP-12 shows dose-dependent neuroprotection in all different models. The effect size depends on the recovery time but also on the extent of the lesion. In cases of mild to moderate lesion pronounced dose-dependent effects could be demonstrated. This indicates that chronic exposure to N-PEP-12 is able to prevent neuronal cell death associated to conditions occurring during normal aging and neurological disorders like ischemic stroke, hypoxia, brain trauma, or AD.
Find related publications in this database (using NLM MeSH Indexing)
Amino Acids - pharmacology
Animals -
Brain Diseases - drug therapy
Cell Aging -
Cell Hypoxia - drug effects
Cell Survival - drug effects
Cells, Cultured -
Cerebral Cortex - cytology
Chick Embryo -
Chickens -
Colchicine - pharmacology
Cytoskeleton - drug effects
Dose-Response Relationship, Drug -
Enzyme Inhibitors - pharmacology
Glutamic Acid - pharmacology
Iodoacetates - pharmacology
Neurons - cytology Neurons - drug effects
Neuroprotective Agents - pharmacology
Neurotoxins - pharmacology
Sodium Cyanide - pharmacology

Find related publications in this database (Keywords)
peptides
growth factors
neuroprotection
brain lesion
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