Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cetin, H; Klickovic, U; Rath, J; Zulehner, G; Füzi, J; Reichardt, B; Hagmann, M; Wanschitz, J; Löscher, WN; Auff, E; Zimprich, F.
Associations between co-medications and survival in ALS-a cohort study from Austria.
J Neurol. 2015; 262(7): 1698-705.
Doi: 10.1007/s00415-015-7767-7
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Klickovic Uros
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- Abstract:
- The aim of this study was to evaluate associations between co-medications and survival of patients with amyotrophic lateral sclerosis (ALS). Prescription databases of the Austrian sickness funds covering more than 5 million people formed the basis of this study. ALS cases were deduced from riluzole prescriptions during the study period from January 1, 2008, to June 30, 2012. After adjusting for potential confounding factors associations between co-medications and ALS survival were analyzed. A total of 522 ALS patients could be identified during the study period. Sixteen of the most frequently used drug classes were considered for the survival analyses of which two were nominally associated with ALS survival. Proton pump inhibitors (PPI) were negatively correlated with survival (HR 1.34, 95 % CI 1.04-1.73) and centrally acting muscle relaxants (CAMR) showed a positive association (HR 0.56, 95 % CI 0.39-0.81). After correcting for multiple testing, the association between CAMR and ALS survival remained significant (p = 0.03). In conclusion, this is the first study systematically evaluating potential associations between commonly used drugs and ALS disease course. We report a positive association between CAMR use and survival, which may have derived from an indication bias representing the better prognosis of the upper motor neuron predominant disease variant. However, this is still interesting since it demonstrates the sensitivity of our study design to pick up survival effects. The use of large prescription registries could thus provide a valuable basis to find clues to underlying pathophysiological mechanisms in ALS.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Amyotrophic Lateral Sclerosis - drug therapy, epidemiology, mortality
- Austria - epidemiology
- Cohort Studies - administration & dosage
- Databases, Factual - statistics & numerical data
- Disease Progression - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Neuroprotective Agents - therapeutic use
- Regression Analysis - administration & dosage
- Riluzole - therapeutic use
- Statistics, Nonparametric - administration & dosage
- Survival Analysis - administration & dosage
- Find related publications in this database (Keywords)
- Amyotrophic lateral sclerosis
- Cohort study
- Co-medication
- Muscle relaxants, central
- Proton pump inhibitors