Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Huber, J; Fröhlich-Reiterer, EE; Sudi, K; Suppan, E; Weinhandl, G; Jasser-Nitsche, H; Aigner, R; Borkenstein, MH.
The influence of physical activity on ghrelin and IGF-1/IGFBP-3 levels in children and adolescents with type 1 diabetes mellitus.
Pediatr Diabetes. 2010; 11(6):383-385
Doi: 10.1111/j.1399-5448.2009.00604.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Höntzsch Julia
- Co-Autor*innen der Med Uni Graz
- Aigner Reingard
- Borkenstein Helmuth Martin
- Fröhlich-Reiterer Elke
- Jasser-Nitsche Hildegard
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- Abstract:
- The aim of the study was to determine the influence of regular physical activity on ghrelin and IGF-1/IGFBP-3 levels during a diabetes camp. Twenty-eight children and adolescents (14 boys; mean age 12.1 yr) with type 1 diabetes mellitus (T1DM, mean duration of diabetes 4.8 yr) attending a 2-wk diabetes camp that features increased regular physical activities have been studied. Serum levels of ghrelin (total and acylated), growth hormone (GH), insulin-like growth factor-1 (IGF-1), insulin-like growth factor-bindng protein-3 (IGFBP-3) and insulin were measured in fasting state on day 1 and day 14. Improvement of metabolic control was documented by haemoglobin A1c (HbA1c). Glucose levels and insulin doses were determined daily. Mean insulin dosage decreased from 0.87 to 0.78 U/kg/d, mean HbA1c levels decreased from 8.6 to 8.3%, but the changes were not statistical. There was a significant decline in total ghrelin. IGFBP-3 and IGF-1 decreased also significantly. Total basal ghrelin was inversely related to the change in IGFBP-3. We hypothesize an association between ghrelin and metabolic control in T1DM. Higher ghrelin levels might be associated with poor metabolic control. The dynamic of IGFBP-3 levels appears to be under the influence of basal ghrelin concentrations in T1DM.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Child -
- Female -
- Ghrelin - blood
- Glycated Hemoglobin A - metabolism
- Human Growth Hormone - blood
- Humans -
- Insulin - blood
- Insulin-Like Growth Factor Binding Protein 3 - blood
- Insulin-Like Growth Factor I - metabolism
- Male -
- Motor Activity - physiology
- Find related publications in this database (Keywords)
- ghrelin
- IGFBP-3
- metabolic control
- physical activity
- T1DM