Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schneditz, D; Mussnig, S; Krenn, S; Hecking, M.
Revisiting the concept of constant tissue conductivities for volume estimation in dialysis patients using bioimpedance spectroscopy.
Int J Artif Organs. 2023; 46(2):67-73
Doi: 10.1177/03913988221145457
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Schneditz Daniel
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- Abstract:
- RATIONALE: Current estimation of body fluid volumes in hemodialysis patients using bioimpedance analysis assumes constant specific electrical characteristics of biological tissues despite a large variation in plasma Na+ concentrations [Na+], ranging from 130 to 150 mmol/L. Here, we examined the potential effect of variable [Na+] on bioimpedance-derived volume overload. METHOD: Volumes were calculated from published whole-body extra- and intracellular resistance data and relationships using either "standard" or "revised" specific electrical characteristics modeled as functions of [Na+]. RESULT: With "standard" assumptions, volumes increased with increasing [Na+]. The increase in volume overload was about 0.5 dm3 and 3% of extracellular volume per 10 mmol/dm3 of [Na+] in a 75 kg patient. This increase was abolished when the same bioimpedance data were analyzed under "revised" conditions. DISCUSSION: The overestimation in extracellular volume overload in the range of 0.5 dm3 per 10 mmol/dm3 [Na+] perfectly matches the positive relationship determined in a large cohort of hemodialysis patients. The bias may be considered moderate when interpreting data of individual patients, but may become important when comparing data of larger patient groups. The bias disappears when analysis of bioimpedance data accounts for differences in tissue electrical properties, using individual [Na+].
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Renal Dialysis - administration & dosage
- Electric Impedance - administration & dosage
- Spectrum Analysis - administration & dosage
- Plasma - administration & dosage
- Sodium - administration & dosage
- Find related publications in this database (Keywords)
- Volume overload
- bioimpedance spectroscopy
- sodium concentration
- conductivity
- modeling
- clinical dialysis