Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mangge, H; Almer, G; Stelzer, I; Reininghaus, E; Prassl, R.
Laboratory medicine for molecular imaging of atherosclerosis.
Clin Chim Acta. 2014; 437(2):19-24
Doi: 10.1016/j.cca.2014.06.029
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Co-Autor*innen der Med Uni Graz
- Almer Gunter
- Prassl Ruth
- Reininghaus Eva
- Stelzer Ingeborg
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- Abstract:
- Atherosclerotic plaques are the main cause of life threatening clinical endpoints like myocardial infarction and stroke. To prevent these endpoints, the improved early diagnosis and treatment of vulnerable atherosclerotic vascular lesions are essential. Although originally applied for anticancer treatment, recent advances have also showed the considerable potential of nanotechnology for atherosclerosis. Otherwise, one domain of laboratory medicine is the investigation of new biomarkers. Recent research activities have identified the usability of biomarker-targeted nanoparticles for molecular imaging and pharmacologic modification of vulnerable atherosclerotic lesions leading to myocardial infarction or stroke. These investigations have established a new research interface between laboratory medicine, nanotechnology, cardiology/neurology, and radiology. In this review, we discuss inflammatory pathophysiologic mechanisms and biomarkers associated with a vulnerable atherosclerotic plaque phenotype. Further, we will emphasize cardiovascular relevant functionalized nanoparticle biomarker constructs which were developed within the cooperation interface between Laboratory Medicine (anti-inflammatory biomarkers), Nano-Medicine (nanoparticle development), and Radiology (molecular imaging). Copyright © 2014 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Atherosclerosis - diagnosis
- Atherosclerosis - immunology
- Atherosclerosis - metabolism
- Humans -
- Inflammation - diagnosis
- Inflammation - immunology
- Inflammation - metabolism
- Molecular Imaging - methods
- Molecular Imaging - trends
- Plaque, Atherosclerotic - diagnosis
- Plaque, Atherosclerotic - immunology
- Plaque, Atherosclerotic - metabolism
- Find related publications in this database (Keywords)
- Laboratory medicine
- Molecular imaging of atherosclerosis
- Nanotechnology