Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hörl, G; Ledinski, G; Kager, G; Hallström, S; Tafeit, E; Koestenberger, M; Jürgens, G; Cvirn, G.
In vitro oxidation of LDL by ozone.
Chem Phys Lipids. 2014; 183(7):18-21
Doi: 10.1016/j.chemphyslip.2014.05.002
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Cvirn Gerhard
- Hörl Gerd
- Co-Autor*innen der Med Uni Graz
- Hallström Seth
- Jürgens Günther
- Kager Gerd
- Koestenberger Martin
- Ledinski Gerhard
- Tafeit Erwin
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- Abstract:
- Recent studies suggest that ozone is present in atherosclerotic lesions. Since these lesions are characterized by a dramatic accumulation of low-density lipoprotein (LDL), we aimed to investigate whether ozone is capable of oxidizing LDL, thereby rendering this lipoprotein atherogenic. Lipid hydroperoxide (LPO) concentrations and thiobarbituric acid reactive substances (TBARS) were measured to assess the oxidative status of the lipid part of LDL. Relative electrophoretic mobility (REM) and oxidation-specific immune epitopes were measured to assess the oxidative status of the protein part (apoB) of the LDL particle. Ozone turned out to be a potent oxidant of LDL. LPO concentrations, TBARS, REM, and oxidation-specific immune epitopes significantly increased upon ozonization. Our results suggest that ozonization of LDL may be a novel pathway which supports atherogenesis. Ozone is capable of oxidizing the lipid part of LDL, followed by immediate oxidation of the protein part of LDL, rendering the lipoprotein atherogenic. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans -
- Kinetics -
- Lipoproteins, LDL - chemistry
- Male -
- Oxidation-Reduction -
- Ozone - chemistry
- Find related publications in this database (Keywords)
- Atherosclerosis
- Lipid hydroperoxides
- Low-density lipoprotein
- Oxidation-specific immune epitopes
- Ozone