Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bayerl, N; Mathy, CS; Bergmann, C; Bäuerle, T; Adams, LC; Nagel, AM; Distler, JHW; Gerhalter, T; Uder, M; Heiss, R; Ellmann, S.
Contemporary 0.55 T MRI to visualize interstitial lung disease - An exploratory study
EUR J RADIOL OPEN. 2026; 16: 100720
Doi: 10.1016/j.ejro.2025.100720
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- Co-Autor*innen der Med Uni Graz
- Gerhalter Teresa
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- Abstract:
- Purpose: To evaluate the feasibility of contemporary 0.55 T MRI for visualizing interstitial lung disease (ILD) compared to high-resolution computed tomography (HRCT) in an exploratory first-experience study. Materials and methods: Thirty participants (mean age 60 +/- 13 years; 13 females) with rheumatologic ILD underwent HRCT and 0.55 T MRI within 31 days. MRI protocols included proton-density-weighted turbo-spin-echo sequences (transverse) and T2-weighted short-tau inversion recovery sequences (coronal). Three blinded radiologists independently assessed overall disease extent, ground-glass opacity (GGO), reticulation, and emphysema using a semi-quantitative scoring system. Differences between modalities were tested using Wilcoxon signedrank tests, and Bland-Altman analysis evaluated systematic bias. Results: Overall disease extent showed no statistically significant difference between low-field MRI and HRCT (median 22.5 % vs. 24.5 %), with excellent interobserver agreement (MRI ICC = 0.94; HRCT ICC = 0.97). MRI significantly overestimated GGO (13.1 % vs. 9.7 %) and underestimated reticulation (8.1 % vs. 11.4 %) compared to HRCT. Bland-Altman analysis confirmed no systematic bias for overall disease extent but consistent overestimation of GGO and underestimation of reticulation on MRI. Conclusions: Contemporary 0.55 T MRI showed no statistically significant difference in overall ILD extent compared to HRCT but tended to overestimate GGO and underestimate reticulation. Despite these limitations,0.55 T MRI represents a promising candidate for future development as a radiation-free alternative for gross disease burden assessment in ILD, warranting further technical refinement before routine clinical use.
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