Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jones, EM; Sourij, C; Stradner, M; Schlenke, P; Sereban, N; Moser, O; Quinlan, R; Short, CE; Harris, BHL; Fertleman, M; Taylor, GP; Oliver, N; Sourij, H; Dominguez-Villar, M.
IL-10- and IL-13-Biased T Cell Responses to SARS-CoV-2 Vaccination in Diabetes.
Eur J Immunol. 2025; 55(12):e70112
Doi: 10.1002/eji.70112
PubMed
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- Co-Autor*innen der Med Uni Graz
- Moser Othmar
- Schlenke Peter
- Sourij Caren
- Sourij Harald
- Stradner Martin Helmut
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- Abstract:
- Type 1 and type 2 diabetes are associated with increased severity and mortality from respiratory virus infections. Vaccination in the general population significantly reduces the risk of severe respiratory viral infection and triggers a strong, polyfunctional, and lasting T cell response in healthy individuals. However, vaccine effectiveness in people with type 1 diabetes is unclear. Here, we studied the magnitude and functional characteristics of vaccine-specific CD4+ and CD8+ T cell responses to vaccination in people with type 1 and type 2 diabetes and compared them to those of people living without diabetes, using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine as a model. We found defects in both CD4+ and CD8+ T cell memory maintenance and the functionality of the vaccine-specific T cells in people with diabetes compared with people without. In those individuals with type 1 and type 2 diabetes who harbored detectable vaccine-specific T cells, they displayed an unfocused, tolerogenic phenotype characterized by increased expression of IL-10 and IL-13 compared with people without diabetes. These results have implications for vaccination strategies for people with diabetes.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Diabetes Mellitus, Type 2 - immunology
- Diabetes Mellitus, Type 1 - immunology
- Interleukin-10 - immunology, metabolism
- SARS-CoV-2 - immunology
- Female - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- CD8-Positive T-Lymphocytes - immunology
- COVID-19 - prevention & control, immunology
- Interleukin-13 - immunology, metabolism
- COVID-19 Vaccines - immunology
- Adult - administration & dosage
- CD4-Positive T-Lymphocytes - immunology
- Vaccination - administration & dosage
- Aged - administration & dosage
- Immunologic Memory - administration & dosage