Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gampawar, P; Hofer, E; Alonso, N.
Analysis of Epigenome-Wide Association Studies.
Methods Mol Biol. 2025; 2885: 717-725.
Doi: 10.1007/978-1-0716-4306-8_35
PubMed
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- Führende Autor*innen der Med Uni Graz
- Gampawar Piyush Gajananrao
- Co-Autor*innen der Med Uni Graz
- Alonso Lopez Nerea
- Hofer Edith
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- Abstract:
- Epigenome-wide association studies (EWAS) investigate epigenetic modifications across the genome in relation to phenotypes of interest. The most commonly studied epigenetic modification in EWAS is DNA methylation, particularly at cytosine-phosphate-guanine (CpG) sites. Despite its potential, few EWAS have been conducted in bone diseases, and replication studies remain limited. Similar to genome-wide association studies, EWAS require rigorous steps for quality control of both samples and probes to ensure reliable results. Association analyses can focus on individual differentially methylated probes or adopt a regional approach to identify differentially methylated regions, providing insights into epigenetic contributions to disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Genome-Wide Association Study - methods
- Humans - administration & dosage
- DNA Methylation - administration & dosage
- Epigenesis, Genetic - administration & dosage
- Epigenome - administration & dosage
- Epigenomics - methods
- CpG Islands - administration & dosage