Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moissl, AP; Delgado, GE; Scharnagl, H; Siekmeier, R; Krämer, BK; Duerschmied, D; März, W; Kleber, ME.
Comparing Inflammatory Biomarkers in Cardiovascular Disease: Insights from the LURIC Study.
Int J Mol Sci. 2025; 26(15):
Doi: 10.3390/ijms26157335
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- Co-Autor*innen der Med Uni Graz
- März Winfried
- Scharnagl Hubert
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- Abstract:
- Inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), and interleukin-6 (IL-6), have been associated with an increased risk of future cardiovascular events. While they provide valuable prognostic information, these associations do not necessarily imply a direct causal role. The combined prognostic utility of these markers, however, remains insufficiently studied. We analysed 3300 well-characterised participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, all of whom underwent coronary angiography. Participants were stratified based on their serum concentrations of hsCRP, SAA, and IL-6. Associations between biomarker combinations and mortality were assessed using multivariate Cox regression and ROC analysis. Individuals with elevated hsCRP and SAA or IL-6 showed higher prevalence rates of coronary artery disease, heart failure, and adverse metabolic traits. These "both high" groups had lower estimated glomerular filtration rate, higher NT-proBNP, and increased HbA1c. Combined elevations of hsCRP and SAA were significantly associated with higher all-cause and cardiovascular mortality in partially adjusted models. However, these associations weakened after adjusting for IL-6. IL-6 alone demonstrated the highest predictive power (AUC: 0.638) and improved risk discrimination when included in multi-marker models. The co-elevation of hsCRP, SAA, and IL-6 identifies a high-risk phenotype characterised by greater cardiometabolic burden and increased mortality. IL-6 may reflect upstream inflammatory activity and could serve as a therapeutic target. Multi-marker inflammatory profiling holds promise for refining cardiovascular risk prediction and advancing personalised prevention strategies.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Biomarkers - blood
- Male - administration & dosage
- Female - administration & dosage
- C-Reactive Protein - metabolism, analysis
- Serum Amyloid A Protein - metabolism, analysis
- Middle Aged - administration & dosage
- Cardiovascular Diseases - blood, mortality
- Interleukin-6 - blood
- Aged - administration & dosage
- Inflammation - blood
- Prognosis - administration & dosage
- Risk Factors - administration & dosage
- Find related publications in this database (Keywords)
- serum amyloid A
- cardiovascular risk
- mortality
- high-sensitive C-reactive protein (hsCRP)
- interleukin-6
- inflammation
- biomarkers
- risk stratification