Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle, MA; Seidel, MG; Kashofer, K; Liegl-Atzwanger, B; Sadoghi, P; Müller, DA; Leithner, A.
Precision medicine in diagnosis, prognosis, and disease monitoring of bone and soft tissue sarcomas using liquid biopsy: a systematic review.
Arch Orthop Trauma Surg. 2025; 145(1): 121
Doi: 10.1007/s00402-024-05711-w
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- Führende Autor*innen der Med Uni Graz
- Leithner Andreas
- Smolle Maria Anna
- Co-Autor*innen der Med Uni Graz
- Kashofer Karl
- Liegl-Atzwanger Bernadette
- Sadoghi Patrick
- Seidel Markus
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- Abstract:
- INTRODUCTION: Liquid biopsy as a non-invasive method to investigate cancer biology and monitor residual disease has gained significance in clinical practice over the years. Whilst its applicability in carcinomas is well established, the low incidence and heterogeneity of bone and soft tissue sarcomas explains the less well-established knowledge considering liquid biopsy in these highly malignant mesenchymal neoplasms. MATERIALS AND METHODS: A systematic literature review adhering to the PRISMA guidelines initially identified 920 studies, of whom 68 original articles could be finally included, all dealing with clinical applicability of liquid biopsy in sarcoma. Studies were discussed within two main chapters, i.e. translocation-associated and complex-karyotype sarcomas. RESULTS: Overall, data on clinical applicability of liquid biopsy in 2636 patients with > 10 different entities of bone and soft tissue sarcomas could be summarised. The five most frequent tumour entities included osteosarcoma (n = 602), Ewing sarcoma (n = 384), gastrointestinal stromal tumour (GIST; n = 203), rhabdomyosarcoma (n = 193), and leiomyosarcoma (n = 145). Of 11 liquid biopsy analytes, largest evidence was present for ctDNA and cfDNA, investigated in 26 and 18 studies, respectively. CONCLUSIONS: This systematic literature review provides an extensive up-to-date overview about the current and potential future uses of different liquid biopsy modalities as diagnostic, prognostic, and disease monitoring markers in sarcoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Liquid Biopsy - methods
- Sarcoma - diagnosis, genetics
- Bone Neoplasms - diagnosis, genetics
- Prognosis - administration & dosage
- Soft Tissue Neoplasms - diagnosis, genetics
- Precision Medicine - methods
- Osteosarcoma - diagnosis, genetics
- Find related publications in this database (Keywords)
- Liquid biopsy
- Soft tissue sarcoma
- Bone sarcoma
- Circulating tumour DNA