Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kohlmaier, B; Schweintzger, NA; Sagmeister, MG; Švendová, V; Kohlfürst, DS; Sonnleitner, A; Leitner, M; Berghold, A; Schmiedberger, E; Fazekas, F; Pichler, A; Rejc-Marko, J; Růžek, D; Dufková, L; Čejková, D; Husa, P; Pýchová, M; Krbková, L; Chmelík, V; Štruncová, V; Zavadska, D; Karelis, G; Mickiene, A; Zajkowska, J; Bogovič, P; Strle, F; Zenz, W; The, Eu-Tick-Bo, Study.
Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017.
Microorganisms. 2021; 9(7):
Doi: 10.3390/microorganisms9071420
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- Führende Autor*innen der Med Uni Graz
- Kohlmaier Benno
- Zenz Werner
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Fazekas Franz
- Kohlfürst Daniela
- Leitner Manuel
- Pichler Alexander
- Sagmeister Manfred Gerald
- Schmiedberger Erich
- Schweintzger Nina
- Sonnleitner Astrid
- Svendova Vendula
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- Abstract:
- Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease.
- Find related publications in this database (Keywords)
- tick-borne encephalitis
- vaccine-preventable disease
- meningomyelitis
- central paresis
- peripheral paresis