Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ludwig, H; Evstatiev, R; Kornek, G; Aapro, M; Bauernhofer, T; Buxhofer-Ausch, V; Fridrik, M; Geissler, D; Geissler, K; Gisslinger, H; Koller, E; Kopetzky, G; Lang, A; Rumpold, H; Steurer, M; Kamali, H; Link, H.
Iron metabolism and iron supplementation in cancer patients.
Wien Klin Wochenschr. 2015; 127(23-24):907-919
Doi: 10.1007/s00508-015-0842-3
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- Co-Autor*innen der Med Uni Graz
- Bauernhofer Thomas
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- Abstract:
- Iron deficiency and iron deficiency-associated anemia are common complications in cancer patients. Most iron deficient cancer patients present with functional iron deficiency (FID), a status with adequate storage iron, but insufficient iron supply for erythroblasts and other iron dependent tissues. FID is the consequence of the cancer-associated cytokine release, while in absolute iron deficiency iron stores are depleted resulting in similar but often more severe symptoms of insufficient iron supply. Here we present a short review on the epidemiology, pathophysiology, diagnosis, clinical symptoms, and treatment of iron deficiency in cancer patients. Special emphasis is given to intravenous iron supplementation and on the benefits and limitations of different formulations. Based on these considerations and recommendations from current international guidelines we developed recommendations for clinical practice and classified the level of evidence and grade of recommendation according to the principles of evidence-based medicine.
- Find related publications in this database (using NLM MeSH Indexing)
- Anemia, Iron-Deficiency - etiology
- Anemia, Iron-Deficiency - metabolism
- Anemia, Iron-Deficiency - prevention & control
- Anemia, Iron-Deficiency -
- Dietary Supplements - standards
- Evidence-Based Medicine -
- Humans -
- Iron - metabolism
- Iron - therapeutic use
- Medical Oncology - standards
- Neoplasms - complications
- Neoplasms - drug therapy
- Neoplasms - metabolism
- Practice Guidelines as Topic -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Iron deficiency
- Functional and absolute iron deficiency
- Tumor anemia
- Iron supplementation
- Recommendations for clinical practice